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The patients were classified at the final evaluation into two subgroups according to the duration of TIV use or disease stage measured by communication impairment. We identified non\u2010motor manifestations and investigated their frequencies and differences across the stages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The non\u2010motor manifestations were macroglossia (22.4%), unstable blood pressure (38.8%), hypothermia (26.9%), dysuria (50.7%), and hyperglycemia (12.1%). These manifestations occurred significantly more frequently in patients with TIV \u22655 years than in patients with TIV &lt;5 years, and more in patients with severe communication impairment than in those with preserved communication ability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Non\u2010motor manifestations are observed at a high rate in ALS patients with TIV, and are possibly related to disease progression. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>57<\/jats:bold>: 735\u2013741, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26004","type":"journal-article","created":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T16:37:07Z","timestamp":1509727027000},"page":"735-741","source":"Crossref","is-referenced-by-count":21,"title":["Non\u2010motor manifestations in ALS patients with tracheostomy and invasive 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