{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:44:30Z","timestamp":1789854270691,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T00:00:00Z","timestamp":1516665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Volumetric muscle loss (VML) occurs following significant traumatic injury or surgical removal of skeletal muscle, resulting in nonrecoverable loss of tissue and long\u2010term dysfunction. Perhaps less recognized is that VML injuries inherently disrupt the neuromuscular unit, resulting in fiber denervation and presumptive motor unit rearrangement, expansion, and\/or loss. To characterize neural dysfunction we quantified motoneuron axotomy, in efforts to understand how this relates to the temporal coordination of neuromuscular and morphological alterations due to injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In an established rat tibialis anterior (TA) VML injury model, we examined the motoneuron, skeletal muscle, and maximal isometric torque at 3, 7, 14, and 21 days postinjury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Significant axotomy of 57\u201379% of all TA muscle motoneurons was observed through 21 days postinjury, which was coupled with a 45\u201390% TA maximal torque deficit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      A \u223c20% partial ablation of the TA muscle causes disproportionate damage across the motor unit acutely postinjury.\n                      <jats:italic>Muscle Nerve<\/jats:italic>\n                      <jats:bold>57<\/jats:bold>\n                      : 799\u2013807, 2018\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.26016","type":"journal-article","created":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T11:05:16Z","timestamp":1510830316000},"page":"799-807","source":"Crossref","is-referenced-by-count":60,"title":["Impact of volumetric muscle loss injury on persistent motoneuron axotomy"],"prefix":"10.1002","volume":"57","author":[{"given":"Benjamin T.","family":"Corona","sequence":"first","affiliation":[{"name":"Extremity Trauma and Regenerative Medicine Task Area, United States Army Institute of Surgical Research, 3698 Chambers Pass, BHT1, Fort Sam Houston Texas 78234 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