{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T15:26:52Z","timestamp":1783006012149,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T00:00:00Z","timestamp":1515369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004477","name":"US","doi-asserted-by":"publisher","award":["R01NS092713"],"award-info":[{"award-number":["R01NS092713"]}],"id":[{"id":"10.13039\/501100004477","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16SDG27250236"],"award-info":[{"award-number":["16SDG27250236"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["RG\u20101507\u201005318"],"award-info":[{"award-number":["RG\u20101507\u201005318"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004329","name":"Genzyme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Agrin is essential for the formation and maintenance of neuromuscular junctions (NMJs). NT\u20101654 is a C\u2010terminal fragment of mouse neural agrin. In this study, we determined the effects of NT\u20101654 on the severity of experimental autoimmune myasthenia gravis (EAMG). <jats:italic>Methods<\/jats:italic>: EAMG was induced in female Lewis rats by immunization with the Torpedo acetylcholine receptor (tAChR) and complete Freund's adjuvant (CFA). NT\u20101654 was dissolved in phosphate\u2010buffered saline (PBS) and injected daily subcutaneously into tAChR immunized rats during the first 10 days after immunization, and then every other day for the following 20 days. <jats:italic>Results<\/jats:italic>: We showed that NT\u20101654 attenuated clinical severity, effectively promoted the clustering of AChRs at NMJs, and alleviated the impairment of NMJ transmission and the reduction of muscle\u2010specific kinase (MuSK) in EAMG rats. <jats:italic>Discussion<\/jats:italic>: We demonstrated that NT\u20101654 attenuated clinical severity, effectively promoted the clustering of AChRs at NMJs, and alleviated the impairment of NMJ transmission and the reduction of muscle\u2010specific kinase (MuSK) in EAMG rats. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>57<\/jats:bold>: 814\u2013820, 2018<\/jats:p>","DOI":"10.1002\/mus.26025","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T16:57:52Z","timestamp":1511974672000},"page":"814-820","source":"Crossref","is-referenced-by-count":16,"title":["Engineered agrin attenuates the severity of experimental autoimmune myasthenia gravis"],"prefix":"10.1002","volume":"57","author":[{"given":"Zhiguo","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology Barrow Neurological Institute, St. Joseph's Hospital and Medical Center Phoenix Arizona 85013 USA"},{"name":"Department of Neurology Tianjin Neurological Institute, Tianjin Medical University General Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minshu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Barrow Neurological Institute, St. Joseph's Hospital and Medical Center Phoenix Arizona 85013 USA"},{"name":"Department of Neurology Tianjin 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