{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T02:41:51Z","timestamp":1774060911224,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T00:00:00Z","timestamp":1513728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006937","name":"National Center for Medical Rehabilitation Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006937","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction:<\/jats:italic> This study aimed to identify infections in patients with myasthenia gravis, dermatomyositis, and chronic inflammatory demyelinating polyradiculoneuropathy, and to investigate the relationship between infection and immunomodulation. <jats:italic>Methods:<\/jats:italic> A retrospective chart review examined 631 patients with myasthenia gravis (<jats:italic>n<\/jats:italic>\u2009=\u2009358), chronic inflammatory demyelinating polyradiculoneuropathy (<jats:italic>n<\/jats:italic>\u2009=\u2009124), and dermatomyositis (<jats:italic>n<\/jats:italic>\u2009=\u2009149) patients over a 10\u2010year time period. <jats:italic>Results:<\/jats:italic> Infection rates were similar at approximately 19% in all 3 diseases. Of the infections in which a causative organism was identified, pneumonia, sepsis, and opportunistic infections were the leading diagnoses. A multivariate model demonstrated a significant association between infection and an increased dose of plasma exchange, mycophenolate mofetil, and corticosteroid therapy. <jats:italic>Discussion:<\/jats:italic> There are few large studies investigating rates of infections in patients with autoimmune neuromuscular disorders and the relationship to immunomodulation. This study not only demonstrates the remarkably similar infection rates across the 3 diseases studied, but also shows their relationship to commonly used immunotherapies.  <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>57<\/jats:bold>: 927\u2013931, 2018<\/jats:p>","DOI":"10.1002\/mus.26032","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T20:36:45Z","timestamp":1512592605000},"page":"927-931","source":"Crossref","is-referenced-by-count":25,"title":["Infections and the relationship to treatment in neuromuscular autoimmunity"],"prefix":"10.1002","volume":"57","author":[{"given":"Devin E.","family":"Prior","sequence":"first","affiliation":[{"name":"Department of Neuroscience The Ohio State University Wexner Medical Center Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Nurre","sequence":"additional","affiliation":[{"name":"Department of Neuroscience The Ohio State University Wexner Medical Center Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie L.","family":"Roller","sequence":"additional","affiliation":[{"name":"Department of Neuroscience The Ohio State University Wexner Medical Center Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Kline","sequence":"additional","affiliation":[{"name":"Center for Biostatistics, Department of Biomedical Informatics The Ohio State University Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramit","family":"Panara","sequence":"additional","affiliation":[{"name":"Department of Neuroscience The Ohio State University Wexner Medical Center Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7793-6662","authenticated-orcid":false,"given":"Amro M.","family":"Stino","sequence":"additional","affiliation":[{"name":"Department of Neuroscience The Ohio State University Wexner Medical Center Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease The Ohio State University Wexner Medical Center Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam L.","family":"Freimer","sequence":"additional","affiliation":[{"name":"Department of Neuroscience The Ohio State University Wexner Medical Center Columbus Ohio USA"},{"name":"Department of Neurology, Division of Neuromuscular Medicine The Ohio State University Wexner Medical Center 395 West 12th Avenue Columbus Ohio 43210 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. David","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Neuroscience The Ohio State University Wexner Medical Center Columbus Ohio USA"},{"name":"Department of Neurology, Division of Neuromuscular Medicine The Ohio State University Wexner Medical Center 395 West 12th Avenue Columbus Ohio 43210 USA"},{"name":"Department of Physical Medicine and Rehabilitation The Ohio State University Wexner Medical Center Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03019.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02930.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-015-0394-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq279"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2010.08.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541-0420.00067"},{"key":"e_1_2_7_8_1","first-page":"178","article-title":"Central nervous system infection caused by Aspergillus fumigatus. A complication of immunosuppressive therapy in myasthenia gravis [in German]","volume":"60","author":"Nau R","year":"1989","journal-title":"Der Nervenarzt"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/13550280903493906"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2012.04.016"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-015-0226-2"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.11150\/kansenshogakuzasshi1970.64.1394"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12402"},{"key":"e_1_2_7_14_1","first-page":"289","article-title":"Mycobacterium tuberculosis infection in patients with systemic rheumatic diseases. A case\u2010series","volume":"17","author":"Hernandez\u2010Cruz B","year":"1999","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-4-63"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365540410015222"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.070177"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090843"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2013-000727"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21997"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001077"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.26032","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.26032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:38:08Z","timestamp":1695501488000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.26032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,20]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1002\/mus.26032"],"URL":"https:\/\/doi.org\/10.1002\/mus.26032","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,20]]}}}