{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:46:34Z","timestamp":1789908394773,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T00:00:00Z","timestamp":1517529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KFO219"],"award-info":[{"award-number":["KFO219"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Introduction<\/jats:italic>\n                    : 3,4\u2010diaminopyridine has been used to treat Lambert\u2010Eaton myasthenia (LEM) for 30 years despite the lack of conclusive evidence of efficacy.\n                    <jats:italic>Methods<\/jats:italic>\n                    : We conducted a randomized double\u2010blind placebo\u2010controlled withdrawal study in patients with LEM who had been on stable regimens of 3,4\u2010diaminopyridine base (3,4\u2010DAP) for\u2009\u2265\u20093 months. The primary efficacy endpoint was &gt;30% deterioration in triple timed up\u2010and\u2010go (3TUG) times during tapered drug withdrawal. The secondary endpoint was self\u2010assessment of LEM\u2013related weakness (W\u2010SAS).\n                    <jats:italic>Results<\/jats:italic>\n                    : Thirty\u2010two participants were randomized to continuous 3,4\u2010DAP or placebo groups. None of the 14 participants who received continuous 3,4\u2010DAP had\u2009&gt;\u200930% deterioration in 3TUG time versus 72% of the 18 who tapered to placebo (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.0001). W\u2010SAS similarly demonstrated an advantage for continuous treatment over placebo (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Requirement for rescue and adverse events were more common in the placebo group.\n                    <jats:italic>Discussion<\/jats:italic>\n                    : This trial provides significant evidence of efficacy of 3,4\u2010DAP in the maintenance of strength in LEM.\n                    <jats:italic>Muscle Nerve<\/jats:italic>\n                    <jats:bold>57<\/jats:bold>\n                    : 561\u2013568, 2018\n                  <\/jats:p>","DOI":"10.1002\/mus.26052","type":"journal-article","created":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T07:18:49Z","timestamp":1514359129000},"page":"561-568","source":"Crossref","is-referenced-by-count":42,"title":["3,4\u2010diaminopyridine base effectively treats the weakness of Lambert\u2010Eaton myasthenia"],"prefix":"10.1002","volume":"57","author":[{"given":"Donald B.","family":"Sanders","sequence":"first","affiliation":[{"name":"Department of Neurology Duke University Medical Center, Box 3403 Durham North Carolina 27710 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vern C.","family":"Juel","sequence":"additional","affiliation":[{"name":"Department of Neurology Duke University Medical Center, Box 3403 Durham North Carolina 27710 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadollah","family":"Harati","sequence":"additional","affiliation":[{"name":"Department of Neurology Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Gordon","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Utah School of Medicine Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda C.","family":"Peltier","sequence":"additional","affiliation":[{"name":"Department of Neurology Vanderbilt Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa","family":"Marburger","sequence":"additional","affiliation":[{"name":"Department of Neurology, Oregon Health and Science University Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jau\u2010Shin","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Neurology University of North Dakota School of Medicine &amp; Health Science Fargo North Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Pascuzzi","sequence":"additional","affiliation":[{"name":"Department of Neurology Indiana University Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Richman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Neuroscience University of California Davis, Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai","family":"Xie","sequence":"additional","affiliation":[{"name":"Brightech International LLC Somerset New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Demmel","sequence":"additional","affiliation":[{"name":"nabios GMBH Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura R.","family":"Jacobus","sequence":"additional","affiliation":[{"name":"Jacobus Pharmaceutical Company Princeton New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy L.","family":"Ale\u0161","sequence":"additional","affiliation":[{"name":"Jacobus Pharmaceutical Company Princeton New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Jacobus","sequence":"additional","affiliation":[{"name":"Jacobus Pharmaceutical Company Princeton New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Dapper Study Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,2]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"156","volume-title":"Myasthenia gravis and myasthenic disorders","author":"Juel VC","year":"2015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3233\/JND-140045","article-title":"The edipemiology of neuromuscular disorders: a comprehensive overview of the literature","volume":"2","author":"Deenen JCW","year":"2015","journal-title":"J Neuromuscular Dis"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25520"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb10992.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.46.7.684"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.10.1324"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198912073212303"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.3.603"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2009.35"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21422"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25070"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/81.2.810"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25700"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20090126"},{"issue":"14","key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"P7.066","DOI":"10.1212\/WNL.84.14_supplement.P7.066","article-title":"Predicting responsiveness to study drug before randomization in the DAPPER trial of 3,4\u2010diaminopyridine in Lambert\u2010Eaton myasthenic syndrome (Abstract)","volume":"84","author":"Sanders DB","year":"2015","journal-title":"Neurology"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.235572.2"},{"key":"e_1_2_7_18_1","first-page":"371","article-title":"The Lower Extremity Functional Scale (LEFS): scale development, measurement properties and clinical application","volume":"79","author":"Binkley JM","year":"1999","journal-title":"Phys Ther"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12218"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1993.tb04205.x"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.26052","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.26052","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.26052","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.26052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T23:45:04Z","timestamp":1719704704000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.26052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,2]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1002\/mus.26052"],"URL":"https:\/\/doi.org\/10.1002\/mus.26052","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,2]]}}}