{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:27:57Z","timestamp":1791041277304,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T00:00:00Z","timestamp":1515628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Neuronal calcium channel antibodies are a biomarker of Lambert\u2010Eaton syndrome (LES) and cerebellar ataxia. We have encountered several patients with LES and cerebellar ataxia coexisting, and we sought to further define this association. <jats:italic>Methods<\/jats:italic>: We reviewed records of patients at our institution with a diagnosis of \u201cLambert\u2010Eaton syndrome\u201d and \u201ccerebellar ataxia.\u201d <jats:italic>Results<\/jats:italic>: Seventeen patients were identified with LES and ataxia. Presenting symptoms were weakness (8), concurrent weakness and ataxia (4), ataxia (4), and other (1). Nine patients had small\u2010cell lung carcinoma, 3 of whom had survival greater than 100 months. Immunotherapy responses were best among patients without cancer. Nine of 17 (53%) patients were alive at last follow\u2010up (median survival 62 months; range, 8\u2013240). <jats:italic>Discussion<\/jats:italic>: Calcium channel autoimmunity should be considered in patients with coexisting cerebellar ataxia and myasthenic weakness. Affected patients may survive small\u2010cell carcinoma or have immunotherapy\u2010responsive neurological symptoms. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>58<\/jats:bold>: 29\u201335, 2018<\/jats:p>","DOI":"10.1002\/mus.26053","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T09:31:54Z","timestamp":1514107914000},"page":"29-35","source":"Crossref","is-referenced-by-count":12,"title":["Calcium channel autoimmunity: Cerebellar ataxia and lambert\u2010eaton syndrome coexisting"],"prefix":"10.1002","volume":"58","author":[{"given":"Nicholas","family":"Zalewski","sequence":"first","affiliation":[{"name":"Department of Neurology College of Medicine, Mayo Clinic, 200 1st Street SW Rochester Minnesota 55905 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanda A.","family":"Lennon","sequence":"additional","affiliation":[{"name":"Department of Neurology College of Medicine, Mayo Clinic, 200 1st Street SW Rochester Minnesota 55905 USA"},{"name":"Department of Laboratory Medicine &amp; Pathology College of Medicine Mayo Clinic Rochester Minnesota USA"},{"name":"Immunology College of Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean J.","family":"Pittock","sequence":"additional","affiliation":[{"name":"Department of Neurology College of Medicine, Mayo Clinic, 200 1st Street SW Rochester Minnesota 55905 USA"},{"name":"Department of Laboratory Medicine &amp; Pathology College of Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Mckeon","sequence":"additional","affiliation":[{"name":"Department of Neurology College of Medicine, Mayo Clinic, 200 1st Street SW Rochester Minnesota 55905 USA"},{"name":"Department of Laboratory Medicine &amp; Pathology College of Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199506013322203"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003794"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25027"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.2378"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10392"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0562fje"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1957.02970480021005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.23.7.764"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.8.1279"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.5692\/clinicalneurol.53.104"},{"issue":"9","key":"e_1_2_7_12_1","first-page":"1083","article-title":"Paraneoplastic cerebellar degeneration and Lambert\u2010Eaton myasthenic syndrome associated with anti P\/Q\u2010type voltage\u2010gated calcium channel antibody in a patient with primary double lung cancer [in Japanese]","volume":"61","author":"Iwanami M","year":"2009","journal-title":"Brain Nerve"},{"issue":"12","key":"e_1_2_7_13_1","first-page":"1470","article-title":"Case of anti P\/Q type VGCC antibody positive small lung cell carcinoma that occured with subacute cerebellar degeneration, Lambert\u2010Eaton myasthenic syndrome, and brainstem encephalitis [in Japanese]","volume":"60","author":"Nagayama S","year":"2008","journal-title":"Brain Nerve"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.0440"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.3.652"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)76153-5"}],"container-title":["Muscle &amp; 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