{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:31:43Z","timestamp":1793316703382,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T00:00:00Z","timestamp":1517788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Patients with myasthenia gravis often experience fatigue, but its effect on quality of life (QoL) is underestimated, and fatigue is rarely measured in clinical trials. <jats:italic>Methods<\/jats:italic>: Two hundred fifty\u2010seven myasthenic patients completed the Neuro\u2010QoL\u2010Fatigue and measures of disease severity and QoL. We studied the relationship between fatigue and clinical and demographic variables. Finally, we studied the responsiveness of the Neuro\u2010QoL\u2010Fatigue in 95 patients receiving treatments for myasthenia and estimated the minimal important difference (MID). <jats:italic>Results<\/jats:italic>: Fatigue correlated with greater disease severity (<jats:italic>r<\/jats:italic>\u2009=\u20090.52\u20130.69, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) and worse QoL (<jats:italic>r<\/jats:italic>\u2009=\u20090.65\u20130.75, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Patients in remission, with minimal manifestations, and pure ocular symptoms reported minimal fatigue. Regression modeling showed that, in addition to its relationship with disease severity, fatigue was worse in females, patients with generalized disease, and those with anxiety\/depression. Fatigue improved after immunomodulation (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), and the MID was 5.3 points. <jats:italic>Discussion<\/jats:italic>: Fatigue in myasthenia correlates with disease severity, affects QoL, and can improve after treatment. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>58<\/jats:bold>: 197\u2013203, 2018<\/jats:p>","DOI":"10.1002\/mus.26069","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T17:17:16Z","timestamp":1516209436000},"page":"197-203","source":"Crossref","is-referenced-by-count":51,"title":["Fatigue is a relevant outcome in patients with myasthenia gravis"],"prefix":"10.1002","volume":"58","author":[{"given":"Christopher","family":"Tran","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Schulich School of Medicine &amp; Dentistry Western University London Ontario Canada"},{"name":"Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Toronto General Hospital Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Bril","sequence":"additional","affiliation":[{"name":"Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Toronto General Hospital Toronto Ontario Canada"},{"name":"Division of Neurology, Department of Medicine University Health Network and University of Toronto 200 Elizabeth Street, 5EC Room 344, Toronto Ontario M5G 2C4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans D.","family":"Katzberg","sequence":"additional","affiliation":[{"name":"Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Toronto General Hospital Toronto Ontario Canada"},{"name":"Division of Neurology, Department of Medicine University Health Network and University of Toronto 200 Elizabeth Street, 5EC Room 344, Toronto Ontario M5G 2C4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5546-0221","authenticated-orcid":false,"given":"Carolina","family":"Barnett","sequence":"additional","affiliation":[{"name":"Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Toronto General Hospital Toronto Ontario Canada"},{"name":"Division of Neurology, Department of Medicine University Health Network and University of Toronto 200 Elizabeth Street, 5EC Room 344, Toronto Ontario M5G 2C4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4598(200009)23:9<1402::AID-MUS11>3.0.CO;2-B"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.538"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968308315046"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098089"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2010.03.028"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-017-0649-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002971"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318258f744"},{"key":"e_1_2_7_10_1","unstructured":"National Institute of Neurological Disorders and Stroke.User manual for the Quality of Life in Neurological Disorders (Neuro\u2010QoL) measures version 2.0. 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