{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:53:12Z","timestamp":1786978392584,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T00:00:00Z","timestamp":1524182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"\u201cOpening the Future\u201d","award":["EJJ-OPTFUT-02010"],"award-info":[{"award-number":["EJJ-OPTFUT-02010"]}]},{"name":"\u201cOpening the Future\u201d","award":["CARIPLO 2015_0634"],"award-info":[{"award-number":["CARIPLO 2015_0634"]}]},{"name":"\u201cOpening the Future\u201d","award":["FWO G088715N G060612N G0A8813N"],"award-info":[{"award-number":["FWO G088715N G060612N G0A8813N"]}]},{"name":"\u201cOpening the Future\u201d","award":["GOA EJJ-C2161-GOA\/11\/012"],"award-info":[{"award-number":["GOA EJJ-C2161-GOA\/11\/012"]}]},{"name":"\u201cOpening the Future\u201d","award":["IUAP-VII\/07"],"award-info":[{"award-number":["IUAP-VII\/07"]}]},{"name":"\u201cOpening the Future\u201d","award":["EJJ-C4851-17\/07-P"],"award-info":[{"award-number":["EJJ-C4851-17\/07-P"]}]},{"name":"\u201cOpening the Future\u201d","award":["OT 09-053 EJJ-C0420-OT\/09\/053"],"award-info":[{"award-number":["OT 09-053 EJJ-C0420-OT\/09\/053"]}]},{"name":"Project Financing Stem Cells","award":["PFO3 10\/019"],"award-info":[{"award-number":["PFO3 10\/019"]}]},{"name":"Rondoufonds voor Duchenne Onderzoek","award":["EQQ-FODUCH-O2010"],"award-info":[{"award-number":["EQQ-FODUCH-O2010"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Introduction<\/jats:italic>\n                    : Limb\u2010girdle muscular dystrophy type 2E (LGMD2E) is caused by mutations in the \u03b2\u2010sarcoglycan gene, which is expressed in skeletal, cardiac, and smooth muscles. \u03b2\u2010Sarcoglycan\u2010deficient (\n                    <jats:italic>Sgcb<\/jats:italic>\n                    \u2010null) mice develop severe muscular dystrophy and cardiomyopathy with focal areas of necrosis.\n                    <jats:italic>Methods<\/jats:italic>\n                    : In this study we performed morphological (histological and cellular characterization) and functional (isometric tetanic force and fatigue) analyses in dystrophic mice. Comparison studies were carried out in 1\u2010month\u2010old (clinical onset of the disease) and 7\u2010month\u2010old control mice (C57Bl\/6J,\n                    <jats:italic>Rag2\/\u03b3c<\/jats:italic>\n                    \u2010null) and immunocompetent and immunodeficient dystrophic mice (\n                    <jats:italic>Sgcb<\/jats:italic>\n                    \u2010null and\n                    <jats:italic>Sgcb\/Rag2\/\u03b3c<\/jats:italic>\n                    \u2010null, respectively).\n                    <jats:italic>Results<\/jats:italic>\n                    : We found that the lack of an immunological system resulted in an increase of calcification in striated muscles without impairing extensor digitorum longus muscle performance.\n                    <jats:italic>Sgcb\/Rag2\/\u03b3c<\/jats:italic>\n                    \u2010null muscles showed a significant reduction of alkaline phosphate\u2010positive mesoangioblasts.\n                    <jats:italic>Discussion<\/jats:italic>\n                    : The immunological system counteracts skeletal muscle degeneration in the murine model of LGMD2E.\n                    <jats:italic>Muscle Nerve<\/jats:italic>\n                    <jats:bold>58<\/jats:bold>\n                    : 133\u2013144, 2018\n                  <\/jats:p>","DOI":"10.1002\/mus.26112","type":"journal-article","created":{"date-parts":[[2018,2,24]],"date-time":"2018-02-24T12:12:35Z","timestamp":1519474355000},"page":"133-144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Morphological and functional analyses of skeletal muscles from an immunodeficient animal model of limb\u2010girdle muscular dystrophy type 2E"],"prefix":"10.1002","volume":"58","author":[{"given":"Gaia","family":"Giovannelli","sequence":"first","affiliation":[{"name":"Department of Neurosciences and Imaging \u201cG. d'Annunzio\u201d University Chieti Italy"},{"name":"Translational Cardiomyology, Stem Cell Research Institute Catholic University of Leuven Herestraat 49 O&amp;N4\u2013Bus 814 Leuven B\u20103000 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Giacomazzi","sequence":"additional","affiliation":[{"name":"Translational Cardiomyology, Stem Cell Research Institute Catholic University of Leuven Herestraat 49 O&amp;N4\u2013Bus 814 Leuven B\u20103000 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Grosemans","sequence":"additional","affiliation":[{"name":"Translational Cardiomyology, Stem Cell Research Institute Catholic University of Leuven Herestraat 49 O&amp;N4\u2013Bus 814 Leuven B\u20103000 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2422-3757","authenticated-orcid":false,"given":"Maurilio","family":"Sampaolesi","sequence":"additional","affiliation":[{"name":"Translational Cardiomyology, Stem Cell Research Institute Catholic University of Leuven Herestraat 49 O&amp;N4\u2013Bus 814 Leuven B\u20103000 Belgium"},{"name":"Human Anatomy Unit, Department of Public Health, Experimental and Forensic Medicine University of Pavia Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199804)21:4<421::AID-MUS1>3.0.CO;2-B"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.122.4.809"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80410-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1050-1738(03)00101-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81975-3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2010.04.008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1195-266"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.11.1841"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(02)00309-X"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2005.07.003"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1114758"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1542"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05282"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm3000716"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1082254"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.75"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2015"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1412"},{"key":"e_1_2_7_20_1","doi-asserted-by":"crossref","first-page":"4152","DOI":"10.4049\/jimmunol.158.9.4152","article-title":"CD8Tc1 and Tc2 cells secrete distinct cytokine patterns in vitro and in vivo but induce similar inflammatory reactions","volume":"158","author":"Li L","year":"1997","journal-title":"J Immunol"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/clim.2000.4966"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780092"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.10.054"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540205000108"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.3A6210.2004"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.060"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1179\/174313208X281046"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI82735"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.022673"},{"key":"e_1_2_7_30_1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.18388\/abp.2000_3974","article-title":"Animal electricity, Ca2+ and muscle contraction. A brief history of muscle research","volume":"47","author":"Martonosi AN","year":"2000","journal-title":"Acta Biochim Polonica"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1988.sp017279"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1964.0004"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(89)90128-7"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.64.6.2388"},{"key":"e_1_2_7_35_1","first-page":"3059","article-title":"Novel insight into stem cell trafficking in dystrophic muscles","volume":"7","author":"Farini A","year":"2012","journal-title":"Int J Nanomed"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2213"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2013.186"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10974-010-9204-y"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4301"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/491497"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102680"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85782"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01291"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201011099"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-016-0312-5"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3918"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.26112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.26112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T09:03:36Z","timestamp":1694941416000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.26112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,20]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1002\/mus.26112"],"URL":"https:\/\/doi.org\/10.1002\/mus.26112","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,20]]},"assertion":[{"value":"2018-02-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}