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The application of evidence\u2010based medicine (EBM) is the process of converting the abstract task of reading the literature into a practical method of using the literature to inform care in a specific clinical context while simultaneously expanding one's knowledge. EBM involves 4 steps: (1) stating the clinical problem in a defined question; (2) searching the literature for the evidence; (3) critically appraising the evidence for its validity; and (4) applying the evidence in the context of the patient's situation, preferences, and values. In this review, we use the recently published trial of thymectomy in myasthenia gravis as an example and systematically go through the steps of assessing internal validity, precision, and external validity. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>58<\/jats:bold>: 486\u2013496, 2018<\/jats:p>","DOI":"10.1002\/mus.26142","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T20:13:22Z","timestamp":1523996002000},"page":"486-496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evidence\u2010based medicine for every day, everyone, and every therapeutic study"],"prefix":"10.1002","volume":"58","author":[{"given":"Raghav","family":"Govindarajan","sequence":"first","affiliation":[{"name":"Department of Neurology University of Missouri Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9412-7349","authenticated-orcid":false,"given":"Pushpa","family":"Narayanaswami","sequence":"additional","affiliation":[{"name":"Department of Neurology Beth Israel Deaconess Medical Center\/Harvard Medical School Neurology TCC\u20108, 330 Brookline Avenue Boston Massachusetts 02215 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-1842.2002.00382.x"},{"key":"e_1_2_9_3_1","unstructured":"U.S. National Library of Medicine2016.Citations added to MEDLINE\u00aeby fiscal year. 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