{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:21:11Z","timestamp":1791195671393,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T00:00:00Z","timestamp":1534982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Introduction<\/jats:italic>\n                    : Rituximab appears to be beneficial in treatment\u2010refractory myasthenia gravis (MG); however, prospective, long\u2010term durability data are lacking.\n                    <jats:italic>Methods<\/jats:italic>\n                    : In this prospective, open\u2010label study of rituximab in refractory MG, 22 patients (10 nicotinic acetylcholine receptor, 9 muscle\u2010specific tyrosine kinase, 3 seronegative) received rituximab at baseline, with repeat cycles driven by clinical worsening. Manual muscle testing (MMT) scores and CD19\/CD20\n                    <jats:sup>+<\/jats:sup>\n                    B\u2010cell counts were serially monitored.\n                    <jats:italic>Results<\/jats:italic>\n                    : At mean follow\u2010up of 28.8\u2009\u00b1\u200919.0 months (range, 6\u201366), mean MMT scores declined from 10.6\u2009\u00b1\u20095.4 to 3.3\u2009\u00b1\u20093.1 (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Mean prednisone dosage declined from 25.2\u2009\u00b1\u200915.1 to 7.3\u2009\u00b1\u20097.1\u2009mg\/d (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.002). Ten relapses occurred, with average time to first relapse of 17.1\u2009\u00b1\u20095.5 months (range, 9\u201323). CD19\/CD20\n                    <jats:sup>+<\/jats:sup>\n                    count recovery did not predict relapse. Three patients experienced prolonged B\u2010cell depletion (range, 24\u201345 months) after 1 cycle.\n                    <jats:italic>Discussion<\/jats:italic>\n                    : Sustained clinical improvement was associated with rituximab after 1 cycle, with prolonged time to relapse and reduction in steroid dosage.\n                    <jats:italic>Muscle Nerve<\/jats:italic>\n                    <jats:bold>58<\/jats:bold>\n                    : 453\u2013456, 2018\n                  <\/jats:p>","DOI":"10.1002\/mus.26156","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T19:50:49Z","timestamp":1525895449000},"page":"452-455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Rituximab in refractory myasthenia gravis: Extended prospective study results"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3512-1796","authenticated-orcid":false,"given":"Grayson","family":"Beecher","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Neurology University of Alberta 7\u2010132 Clinical Sciences Building, 11350\u201083 Avenue, Edmonton Alberta T6G 2G3 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Neurology University of Alberta 7\u2010132 Clinical Sciences Building, 11350\u201083 Avenue, Edmonton Alberta T6G 2G3 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaeem A.","family":"Siddiqi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Neurology University of Alberta 7\u2010132 Clinical Sciences Building, 11350\u201083 Avenue, Edmonton Alberta T6G 2G3 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25597"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.02.357"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21521"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23412"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182407982"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2008.02399.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756285611411503"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.7.1062-a"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.314"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.4190"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004341"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/CND.0000000000000034"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002790"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1254.057"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22019"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.1.16"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25973"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24063"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.26156","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.26156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T02:44:43Z","timestamp":1694832283000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.26156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,23]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1002\/mus.26156"],"URL":"https:\/\/doi.org\/10.1002\/mus.26156","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.733206787.793552112","asserted-by":"object"}]},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,23]]},"assertion":[{"value":"2018-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}