{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T02:35:36Z","timestamp":1785033336348,"version":"3.55.0"},"reference-count":62,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T00:00:00Z","timestamp":1534982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01DC005935"],"award-info":[{"award-number":["R01DC005935"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01DC008149"],"award-info":[{"award-number":["R01DC008149"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01DC014358"],"award-info":[{"award-number":["R01DC014358"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA225608"],"award-info":[{"award-number":["R01CA225608"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["T32DC009401"],"award-info":[{"award-number":["T32DC009401"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["F31AG054315"],"award-info":[{"award-number":["F31AG054315"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Neuromuscular electrical stimulation (NMES) for the treatment of swallowing disorders is delivered at a variety of stimulation frequencies. We examined the effects of stimulation frequency on tongue muscle plasticity in an aging rat model. <jats:italic>Methods<\/jats:italic>: Eighty\u2010six young, middle\u2010aged, and old rats were assigned to either bilateral hypoglossal nerve stimulation at 10 or 100\u2009H<jats:sc>z<\/jats:sc> (5 days\/week, 8 weeks), sham, or no\u2010implantation conditions. Muscle contractile properties and myosin heavy chain (MyHC) composition were determined for hyoglossus (HG) and styloglossus (SG) muscles. <jats:italic>Results<\/jats:italic>: Eight weeks of 100\u2010H<jats:sc>z<\/jats:sc> stimulation resulted in the greatest changes in muscle contractile function with significantly longer contraction and half\u2010decay times, the greatest reduction in fatigue, and a transition toward slowly contracting, fatigue\u2010resistant MyHC isoforms. <jats:italic>Discussion<\/jats:italic>: NMES at 100\u2010H<jats:sc>z<\/jats:sc> induced considerable changes in contractile and phenotypic profiles of HG and SG muscles, suggesting higher frequency NMES may yield a greater therapeutic effect. <jats:italic>Muscle Nerve<\/jats:italic>, 2018<\/jats:p>","DOI":"10.1002\/mus.26173","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T07:25:27Z","timestamp":1527233127000},"page":"441-448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Effect of neuromuscular electrical stimulation frequency on muscles of the tongue"],"prefix":"10.1002","volume":"58","author":[{"given":"Heidi","family":"Kletzien","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering University of Wisconsin\u2013Madison 1300 University Avenue, Room 481, Madison, Wisconsin 53706 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine and Public Health University of Wisconsin\u2013Madison Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen","family":"Leverson","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine and Public Health University of Wisconsin\u2013Madison Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine P.","family":"Connor","sequence":"additional","affiliation":[{"name":"Department of Communication Sciences and Disorders University of Wisconsin\u2013Madison Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3950\/jibiinkoka.94.541"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1044\/1058-0360(2003\/051)"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1044\/jslhr.4304.1011"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000071019"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2006.11.002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345830620010401"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/55.11.M634"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.14a32.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940711601112"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.156.6.2028863"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1995.268.3.G389"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90013-O"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.1998.00100.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20758"},{"key":"e_1_2_7_16_1","first-page":"466","article-title":"Electrical stimulation for swallowing disorders caused by stroke","volume":"46","author":"Freed ML","year":"2001","journal-title":"Respir Care"},{"key":"e_1_2_7_17_1","first-page":"U2744","article-title":"Emerging modalities in dysphagia rehabilitation: neuromuscular electrical stimulation","volume":"120","author":"Huckabee ML","year":"2007","journal-title":"NZ Med J"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03324749"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1403.2008.00169.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1320040"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940911800401"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940811700407"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-0317"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207450600936254"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940711600107"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-007-9145-9"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-006-9056-1"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-005-9010-7"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-013-9466-9"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-012-9403-3"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-28612-9_6"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-199213050-00003"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.86.3.1002"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199812)21:12<1632::AID-MUS3>3.0.CO;2-W"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2006.12.002"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004180100268"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0029(20000915)50:6<500::AID-JEMT7>3.0.CO;2-7"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1988.sp017226"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1974.0064"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-12-04415.1988"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1960.sp006395"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.2535\/ofaj1936.66.6_405"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2005.02.016"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23499"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/54.11.B492"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199404000-00005"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2008\/059)"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.265bu.x"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01370.2012"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511401010"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-010-9297-x"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2008\/08-0105)"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-007-9103-6"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00914.2010"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/85.4.358"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-011-2128-4"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2009.3045"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.74.2.532"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/70.10.619"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelekin.2007.01.001"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(95)98601-Z"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-011-2086-x"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1440-2440(00)80046-8"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.26173","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.26173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T06:43:25Z","timestamp":1694846605000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.26173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,23]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1002\/mus.26173"],"URL":"https:\/\/doi.org\/10.1002\/mus.26173","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,23]]},"assertion":[{"value":"2017-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}