{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T13:32:17Z","timestamp":1750167137040,"version":"3.37.3"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T00:00:00Z","timestamp":1536710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["FAPESP 2012\/51783\u20102","2013\/21621\u20103","2012\/51783\u20102"],"award-info":[{"award-number":["FAPESP 2012\/51783\u20102","2013\/21621\u20103","2012\/51783\u20102"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Type 1 diabetes mellitus (DM) causes marked skeletal muscle atrophy. Mesenchymal stromal cells (MSC) are an attractive therapy to avoid diabetic complications because of their ability to modify the microenvironment at sites of tissue injury. The objective of this study was to evaluate the effects of MSC transplantation on muscle adaptation caused by diabetes. <jats:italic>Methods<\/jats:italic>: DM was induced by streptozotocin (STZ), and the diabetic animals received systemic MSC transplantation. The von Frey test and footprint analysis were used to assess sensation and sensory motor performance, respectively. Tibialis anterior muscles were investigated by morphology; molecular markers atrogin\u20101\/muscle RING\u2010finger protein\u20101, nuclear factor \u03baB\/p38 mitogen\u2010activated protein kinase, tumor necrosis\u2010like weak inducer of apoptosis\/fibroblast growth factor\u2010inducible 14, myostatin, myogenic differentiation 1, and insulin\u2010like growth factor 1 were also assessed. <jats:italic>Results<\/jats:italic>: MSC transplantation improved sensation and walking performance and also decreased muscle fibrosis in DM rats by modulating atrogenes but did not prevent muscle atrophy. <jats:italic>Discussion<\/jats:italic>: MSCs can reduce muscle and functional complications that result from type 1 DM in rats. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>58<\/jats:bold>: 583\u2013591, 2018<\/jats:p>","DOI":"10.1002\/mus.26196","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T14:14:02Z","timestamp":1532096042000},"page":"583-591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of mesenchymal stromal cells on type 1 diabetes mellitus rat muscles"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3454-5327","authenticated-orcid":false,"given":"Maria Augusta","family":"Sabadine","sequence":"first","affiliation":[{"name":"Department of Medicine Federal University of S\u00e3o Carlos, Rodovia Washington Lu\u00eds, Km 235 \u2010 SP310, CEP: 13565\u2010905  S\u00e3o Carlos\/SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago Luiz","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Federal University of S\u00e3o Carlos  S\u00e3o Carlos SP 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