{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:16:15Z","timestamp":1789827375410,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T00:00:00Z","timestamp":1543449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006197","name":"Fonden til L\u00e6gevidenskabens Fremme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The objective of this study was to evaluate a recently developed motor unit number estimation (MUNE) method, MScanFit MUNE (MScan), as a measure of disease progression in amyotrophic lateral sclerosis (ALS) compared with compound muscle action potential (CMAP) amplitude and 2 traditional MUNE methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>ALS patients were evaluated clinically using the ALS Functional Rating Scale\u2014Revised (ALSFRS\u2010R). MScan, multiple\u2010point stimulation MUNE (MPS), and motor unit number index (MUNIX) were performed in the abductor pollicis brevis (APB) muscle at baseline (27 patients), 4 months (23 patients), and 8 months (16 patients).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 5 measures, MScan registered the largest decline (8.7% per month), compared with MPS (3.4%), MUNIX (4.8%), CMAP amplitude (2.0%), and ALSFRS\u2010R (1.9%). Only MScan and ALSFRS\u2010R registered significant decrements over 4 and 8 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>MScan may be useful as a sensitive, objective tool for quantifying motor unit loss in ALS.<jats:italic>Muscle Nerve<\/jats:italic><jats:bold>59<\/jats:bold>:82\u201387, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26304","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T18:13:42Z","timestamp":1532024022000},"page":"82-87","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Following disease progression in motor neuron disorders with 3 motor unit number estimation methods"],"prefix":"10.1002","volume":"59","author":[{"given":"Anna Bystrup","family":"Jacobsen","sequence":"first","affiliation":[{"name":"Department of Clinical Neurophysiology Aarhus University Hospital N\u00f8rrebrogade 44, 8000 Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh","family":"Bostock","sequence":"additional","affiliation":[{"name":"Institute of Neurology University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8495-9769","authenticated-orcid":false,"given":"Hatice","family":"Tankisi","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology Aarhus University Hospital N\u00f8rrebrogade 44, 8000 Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199702)20:2<179::AID-MUS7>3.0.CO;2-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20120"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24945"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20838"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2017.03.045"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25256"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2017.07.414"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2018.01.002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00210-5"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880160404"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880181211"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2004.834281"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318225aabf"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2012.03.007"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000162036.76024.AB"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2015-310509"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199911)22:11<1571::AID-MUS13>3.0.CO;2-0"},{"key":"e_1_2_7_20_1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/mus.21495","article-title":"Sensitivity of electrophysiological tests for upper and lower motor neuron dysfunction in ALS: a six\u2010month longitudinal study","volume":"41","author":"Carvalho M","year":"2010","journal-title":"Muscle Nerve"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2012.01.004"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21707"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21680"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2016.11.026"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000260065.57832.87"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-014-0331-9"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2015.12.023"}],"container-title":["Muscle &amp; 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