{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T16:48:01Z","timestamp":1777999681893,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,11,18]],"date-time":"2018-11-18T00:00:00Z","timestamp":1542499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Particular fibroadipose infiltration patterns have been recently described by muscle imaging in congenital and later onset forms of <jats:italic>LMNA<\/jats:italic>\u2010related muscular dystrophies (<jats:italic>LMNA<\/jats:italic>\u2010RD). <jats:italic>Methods<\/jats:italic>: Scores for fibroadipose infiltration of 23 lower limb muscles in 34 patients with <jats:italic>LMNA<\/jats:italic>\u2010RD were collected from heat maps of 2 previous studies. Scoring systems were homogenized. Relationships between muscle infiltration and disease duration and age of onset were modeled with random forests. <jats:italic>Results<\/jats:italic>: The pattern of infiltration differs according to disease duration but not to age of disease onset. The muscles whose progression best predicts disease duration were semitendinosus, biceps femoris long head, gluteus medius, and semimembranosus. <jats:italic>Discussion<\/jats:italic>: In <jats:italic>LMNA<\/jats:italic>\u2010RD, our synthetic analysis of lower limb muscle infiltration did not find major differences between forms with different ages of onset but allowed the identification of muscles with characteristic infiltration during disease progression. Monitoring of these specific muscles by quantitative MRI may provide useful imaging biomarkers in <jats:italic>LMNA<\/jats:italic>\u2010RD. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>58<\/jats:bold>:812\u2013817, 2018<\/jats:p>","DOI":"10.1002\/mus.26312","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T13:13:52Z","timestamp":1533129232000},"page":"812-817","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Muscle imaging in laminopathies: Synthesis study identifies meaningful muscles for follow\u2010up"],"prefix":"10.1002","volume":"58","author":[{"given":"David","family":"G\u00f3Mez\u2010Andr\u00e9s","sequence":"first","affiliation":[{"name":"Neuromuscular Disorders Group, Child Neurology Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Passeig de la Vall d'Hebron 119\u2010129  08035 Barcelona 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Paris Saclay Universities UVSQ University of Versailles, UMR 1179 INSERM Garches  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Quijano\u2010Roy","sequence":"additional","affiliation":[{"name":"APHP, Neuromuscular Disorders Unit, Pediatric Department, CHU Paris IdF Ouest \u2010 H\u00f4pital Raymond Poincar\u00e9, Paris Saclay Universities, UVSQ University of Versailles, UMR 1179 INSERM  Garches France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells5030033"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21417"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/B978-0-444-59565-2.00007-1","article-title":"Emery\u2013Dreifuss muscular dystrophy, laminopathies, and other nuclear envelopathies","volume":"113","author":"Bonne G","year":"2013","journal-title":"Handb Clin Neurol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.9.1453"},{"key":"e_1_2_7_6_1","first-page":"891","article-title":"Genetic localization of a newly recognized autosomal dominant limb\u2010girdle muscular dystrophy with cardiac involvement (LGMD1B) to chromosome 1q11\u201021","volume":"60","author":"Kooi AJ","year":"1997","journal-title":"Am J Hum Genet"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2013.11.010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2010.04.009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21514"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21846"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-23593"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25018"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2015.10.001"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-63-756-946"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0016973"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010933404324"},{"key":"e_1_2_7_17_1","unstructured":"KogalurUB IshwaranH.Random forests for survival regression and classification (RF\u2010SRC) R package version 2.5.0. 2017. 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