{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:35:51Z","timestamp":1778600151464,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T00:00:00Z","timestamp":1538438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n<jats:italic>Introduction<\/jats:italic>: Clinical and electrophysiological studies to measures disease activity in juvenile myasthenia gravis (JMG) are limited. <jats:italic>Methods<\/jats:italic>: Retrospective review of the clinical profile, Myasthenia Gravis Foundation of America (MGFA) scores, serial stimulated jitter analysis (Stim\u2010JA) of the orbicularis oculi muscle, grip strength, and spirometry of patients with JMG who were followed in a multidisciplinary clinic was performed. <jats:italic>Results<\/jats:italic>: Thirteen patients with JMG (9 females) with mean age of 13.2\u2009\u00b1\u20094.8 years and follow\u2010up duration of 25.3\u2009\u00b1\u20098.3 months (range, 6\u201339) with\u2009\u2265\u20092 Stim\u2010JA recordings were included. The mean jitter, mean percentage of apparent single\u2010fiber action potentials (%ASFAP) with increased jitter, and mean %ASFAP with blocking at baseline values (77.3\u2009\u00b1\u200954.7\u2009\u00b5s, 64.3%\u2009\u00b1\u200935.8%, 39%\u2009\u00b1\u200938.6%, respectively) and at follow\u2010up (53\u2009\u00b1\u200945.4\u2009\u00b5s, 51.2%\u2009\u00b1\u200934.5%, 17%\u2009\u00b1\u200929.4%, respectively) were abnormal; however, no statistically significant interval difference was noted. The electrophysiological data correlated significantly with Myasthenia Gravis Foundation of America (MGFA) class. Grip strength and spirometry did not correlate with MGFA class. <jats:italic>Discussion<\/jats:italic>: Stimulated jitter values are sensitive biomarkers in JMG. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>58<\/jats:bold>: 729\u2013732, 2018<\/jats:p>","DOI":"10.1002\/mus.26319","type":"journal-article","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T13:39:58Z","timestamp":1534253998000},"page":"729-732","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Serial Stimulated Jitter Analysis In Juvenile Myasthenia Gravis"],"prefix":"10.1002","volume":"58","author":[{"given":"Shivani","family":"Bhatia","sequence":"first","affiliation":[{"name":"Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haley","family":"Quinlan","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Therapy Services Children's Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney","family":"McCracken","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Department of Pediatrics Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric W.","family":"Price","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Allergy\/Immunology, Cystic Fibrosis and Sleep, Department of Pediatrics Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lokesh","family":"Guglani","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Allergy\/Immunology, Cystic Fibrosis and Sleep, Department of Pediatrics Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumit","family":"Verma","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Department of Pediatrics Emory University School of Medicine, Atlanta, 1605 Chantilly Drive NE, Suite 300  Atlanta Georgia 30324 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25440"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.1.16"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2010.07.012"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2008.02038.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25012"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880150405"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2008.03.008"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23709"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24657"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113637"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034505"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00080312"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.7.1208"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25230"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20908"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.26319","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.26319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T04:42:25Z","timestamp":1694320945000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.26319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,2]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1002\/mus.26319"],"URL":"https:\/\/doi.org\/10.1002\/mus.26319","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,2]]},"assertion":[{"value":"2018-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}