{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:43:13Z","timestamp":1790170993066,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"NCATS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Rasagiline is a monoamine oxidase B (MAO\u2010B) inhibitor with possible neuroprotective effects in patients with amyotrophic lateral sclerosis (ALS). <jats:italic>Methods<\/jats:italic>: We performed a randomized, double\u2010blind, placebo\u2010controlled trial of 80 ALS participants with enrichment of the placebo group with historical controls (<jats:italic>n<\/jats:italic>\u2009=\u2009177) at 10 centers in the United States. Participants were randomized in a 3:1 ratio to 2\u2009mg\/day rasagiline or placebo. The primary outcome was average slope of decline on the ALS Functional Rating Scale\u2014Revised (ALSFRS\u2010R). Secondary measures included slow vital capacity, survival, mitochondrial and molecular biomarkers, and adverse\u2010event reporting. <jats:italic>Results<\/jats:italic>: There was no difference in the average 12\u2010month ALSFRS\u2010R slope between rasagiline and the mixed placebo and historical control cohorts. Rasagiline did not show signs of drug\u2010target engagement in urine and blood biomarkers. Rasagiline was well tolerated with no serious adverse events. <jats:italic>Discussion<\/jats:italic>: Rasagiline did not alter disease progression compared with controls over 12 months of treatment. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>59<\/jats:bold>:201\u2013207, 2019<\/jats:p>","DOI":"10.1002\/mus.26335","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T10:58:15Z","timestamp":1536317895000},"page":"201-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Rasagiline for amyotrophic lateral sclerosis: A randomized, controlled trial"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0790-5315","authenticated-orcid":false,"given":"Jeffrey M.","family":"Statland","sequence":"first","affiliation":[{"name":"Department of Neurology University of Kansas Medical Center  3901 Rainbow Boulevard, MS 2012, Kansas City Kansas, 66160 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Moore","sequence":"additional","affiliation":[{"name":"The Forbes Norris MDA\/ALS Research Center California Pacific Medical Center  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Kansas Medical Center  3901 Rainbow Boulevard, MS 2012, Kansas City Kansas, 66160 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Kansas Medical Center  3901 Rainbow Boulevard, MS 2012, Kansas City Kansas, 66160 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahseen","family":"Mozaffar","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Elman","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pennsylvania  Philadelphia Pennslyvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon P.","family":"Nations","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Mitsumoto","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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