{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:13:14Z","timestamp":1772118794133,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007155","name":"Medical Research Council Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005202","name":"Muscular Dystrophy Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005202","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Introduction<\/jats:italic>\n                    : Biomarkers of disease severity in Charcot\u2013Marie\u2013Tooth disease (CMT) are required to evaluate early responses to treatment. In this study we used magnetic resonance imaging (MRI) to evaluate the relationship between muscle volume and intramuscular fat accumulation with weakness, disability, and impaired gait in affected children and adolescents.\n                    <jats:italic>Methods<\/jats:italic>\n                    : Fifty\u2010five participants underwent MRI of the anterior compartment of the lower leg. Muscle and fat volumes were calculated. Strength was measured using hand\u2010held dynamometry, disability using the CMT Pediatric Scale, and 3\u2010dimensional gait analysis using an 8\u2010camera Vicon Nexus motion capture system.\n                    <jats:italic>Results<\/jats:italic>\n                    : Lower muscle volume was significantly associated with reduced dorsiflexion strength, increased disability, impaired gait profile score, and foot drop. Intramuscular fat accumulation was associated with reduced dorsiflexion strength and impaired gait profile score.\n                    <jats:italic>Discussion<\/jats:italic>\n                    : The MRI protocol described was feasible, reliable, and sensitive to the magnitude of weakness, disability, and walking difficulties in children with CMT.\n                    <jats:italic>Muscle Nerve<\/jats:italic>\n                    <jats:bold>59<\/jats:bold>\n                    :213\u2013217, 2019\n                  <\/jats:p>","DOI":"10.1002\/mus.26352","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T18:59:17Z","timestamp":1538161157000},"page":"213-217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Magnetic resonance imaging of the anterior compartment of the lower leg is a biomarker for weakness, disability, and impaired gait in childhood Charcot\u2013Marie\u2013Tooth disease"],"prefix":"10.1002","volume":"59","author":[{"given":"Kayla M. D.","family":"Cornett","sequence":"first","affiliation":[{"name":"Sydney Children's Hospitals Network (Randwick and Westmead) The University of Sydney  Locked Bag 4001, Westmead, Sydney New South Wales 2145 Australia"},{"name":"Fysiotherapie Centraal  Radboudumc, Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Wojciechowski","sequence":"additional","affiliation":[{"name":"Sydney Children's Hospitals Network (Randwick and Westmead) The University of Sydney  Locked Bag 4001, Westmead, Sydney New South Wales 2145 Australia"},{"name":"Fysiotherapie Centraal  Radboudumc, Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy D.","family":"Sman","sequence":"additional","affiliation":[{"name":"Sydney Children's Hospitals Network (Randwick and Westmead)  Sydney New South Wales Australia"},{"name":"Faculty of Health Sciences The University of Sydney  Sydney New South Wales 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