{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:41:33Z","timestamp":1789591293395,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009899","name":"Bevica Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009899","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Muscle weakness and functional disability have not been evaluated in a population\u2010based study of patients with myasthenia gravis (MG). <jats:italic>Methods<\/jats:italic>: All patients with MG in a well\u2010defined catchment area were identified in the Danish National Patient Registry. Of the 175 eligible patients, 90 participated and were studied using MG\u2010specific scales, isometric dynamometry, and functional tests. Fifty age\u2010 and sex\u2010matched subjects served as controls. <jats:italic>Results<\/jats:italic>: Muscle strength was reduced by 13%, 21%, and 12% for shoulder abduction, knee extension, and ankle extension, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Chair stand and 400\u2010meter walking were impaired by 24% and 23%, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Muscle strength and functional performances were related to MG\u2010specific scales. <jats:italic>Discussion<\/jats:italic>: MG patients have moderately reduced isometric muscle strength and impaired physical performance. Muscle weakness and functional tests relate closely to MG\u2010specific scales, suggesting that dynamometry and functional tests can be used to monitor MG patients and as efficacy parameters in clinical trials. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>59<\/jats:bold>:218\u2013223, 2019<\/jats:p>","DOI":"10.1002\/mus.26356","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T13:09:26Z","timestamp":1539349766000},"page":"218-223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Muscle weakness and functional disability in patients with myasthenia gravis"],"prefix":"10.1002","volume":"59","author":[{"given":"Lotte","family":"Vinge","sequence":"first","affiliation":[{"name":"Department of Neurology Aarhus University Hospital  Noerrebrogade 44, 8000 Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Jakobsen","sequence":"additional","affiliation":[{"name":"Department of Neurology Aarhus University Hospital  Noerrebrogade 44, 8000 Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Neurology Aarhus University Hospital  Noerrebrogade 44, 8000 Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2018.01.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24214"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dc1b1e"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23944"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2018.01.006"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002795"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602489"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2014.11.020"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu442"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2014.06.431"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-011-1975-3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/02701367.1999.10608028"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1123\/jpah.7.5.649"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1954.7.2.218"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810380099"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20950"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-10-46"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(64)90171-6"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00315656"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21493"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12193"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2015.01.022"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/874680"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxs006"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10116"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-13-132"},{"key":"e_1_2_7_28_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3233\/JPD-2012-012111","article-title":"Cardiovascular responses during a submaximal exercise test in patients with Parkinson's disease","volume":"2","author":"Speelman AD","year":"2012","journal-title":"J Parkinsons Dis"},{"key":"e_1_2_7_29_1","first-page":"1","article-title":"Associations between physical function, dual\u2010task performance and cognition in patients with mild Alzheimer's disease","volume":"10","author":"Sobol NA","year":"2015","journal-title":"Aging Ment Health"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000000841"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/gns071"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12562"}],"container-title":["Muscle &amp; 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