{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:43:27Z","timestamp":1793040207796,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: In this study we explored the efficacy of nerve hydrodissection for mild\u2010to\u2010moderate carpal tunnel syndrome (CTS). <jats:italic>Methods<\/jats:italic>: Thirty\u2010four participants were randomly assigned to an intervention group or a control group. One 5\u2010ml dose of normal saline was injected into the intracarpal and subcutaneous regions in subjects of both groups, respectively. The primary outcome measure was the Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) score. Secondary outcomes were cross\u2010sectional area of the median nerve and electrophysiological studies. Assessments were performed before the injection and at 1, 2, 3, and 6 months postintervention. <jats:italic>Results<\/jats:italic>: Compared with the control group, the intervention group showed significantly greater improvement at the second and third posttreatment months according to BCTQ severity score and at all time\u2010points for cross\u2010sectional area of the median nerve (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). <jats:italic>Discussion<\/jats:italic>: Our study demonstrates the therapeutic effects of nerve hydrodissection for mild\u2010to\u2010moderate CTS. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>59<\/jats:bold>:174\u2013180, 2019<\/jats:p>","DOI":"10.1002\/mus.26358","type":"journal-article","created":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T20:44:20Z","timestamp":1539981860000},"page":"174-180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":98,"title":["Nerve hydrodissection for carpal tunnel syndrome: A prospective, randomized, double\u2010blind, controlled trial"],"prefix":"10.1002","volume":"59","author":[{"given":"Yung\u2010Tsan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Tri\u2010Service General Hospital, School of Medicine, National Defense Medical Center  No. 325, Sec. 2, Cheng\u2010Kung Road, Neihu District, Taipei Taiwan 11490 Republic of China"},{"name":"Integrated Pain Management Center, Tri\u2010Service General Hospital, School of Medicine, National Defense Medical Center  Taipei Taiwan Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si\u2010Ru","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine School of Medicine, National Defense Medical Center  Taipei Taiwan Republic of 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