{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:28:33Z","timestamp":1789777713543,"version":"4.0.1"},"reference-count":69,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institutes of Health National Institute on Aging","award":["R03AG050877"],"award-info":[{"award-number":["R03AG050877"]}]},{"name":"Neurological Research Institute at The Ohio State University Wexner Medical Center"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Electrophysiological measurements are used in longitudinal clinical studies to provide insight into the progression of amyotrophic lateral sclerosis (ALS) and the relationship between muscle weakness and motor unit (MU) degeneration. Here, we used a similar longitudinal approach in the Cu\/Zn superoxide dismutase (SOD1[G93A]) mouse model of ALS.<jats:italic>Methods: In vivo<\/jats:italic>muscle contractility and MU connectivity assays were assessed longitudinally in SOD1(G93A) and wild type mice from postnatal days 35 to 119.<jats:italic>Results<\/jats:italic>: In SOD1(G93A) males, muscle contractility was reduced by day 35 and preceded MU loss. Muscle contractility and motor unit reduction were delayed in SOD1(G93A) females compared with males, but, just as with males, muscle contractility reduction preceded MU loss.<jats:italic>Discussion<\/jats:italic>: The longitudinal contractility and connectivity paradigm employed here provides additional insight into the SOD1(G93A) mouse model and suggests that loss of muscle contractility is an early finding that may precede loss of MUs and motor neuron death.<jats:italic>Muscle Nerve<\/jats:italic><jats:bold>59<\/jats:bold>:254\u2013262, 2019<\/jats:p>","DOI":"10.1002\/mus.26365","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T05:11:50Z","timestamp":1540789910000},"page":"254-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Muscle contractility dysfunction precedes loss of motor unit connectivity in SOD1(G93A) mice"],"prefix":"10.1002","volume":"59","author":[{"given":"Christopher G.","family":"Wier","sequence":"first","affiliation":[{"name":"Department of Biological Chemistry and Pharmacology The Ohio State University Wexner Medical Center Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander E.","family":"Crum","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Neuromuscular Medicine The Ohio State University Wexner Medical Center 395 West 12th Avenue, Columbus Ohio 43210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony B.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry and Pharmacology The Ohio State University Wexner Medical Center Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitra C.","family":"Iyer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Neuromuscular Medicine The Ohio State University Wexner Medical Center 395 West 12th Avenue, Columbus Ohio 43210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepti","family":"Chugh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Neuromuscular Medicine The Ohio State University Wexner Medical Center 395 West 12th Avenue, Columbus Ohio 43210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilly S.","family":"Palettas","sequence":"additional","affiliation":[{"name":"Center for Biostatistics, Department of Biomedical Informatics The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick L.","family":"Heilman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Neuromuscular Medicine The Ohio State University Wexner Medical Center 395 West 12th Avenue, Columbus Ohio 43210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Kline","sequence":"additional","affiliation":[{"name":"Center for Biostatistics, Department of Biomedical Informatics The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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