{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:48:56Z","timestamp":1791229736365,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,29]],"date-time":"2018-12-29T00:00:00Z","timestamp":1546041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Needle electromyography (EMG) findings help confirm myopathy and may indicate specific pathologic changes on muscle biopsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective chart review of 218 consecutive patients referred for muscle biopsy. Presence of specific needle EMG findings was correlated with pathologic findings of inflammation, necrosis, splitting, and vacuolar changes. Sensitivity, specificity, and positive and negative predictive values of specific EMG findings for pathologic changes were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Short\u2010duration motor unit potentials (MUP) were sensitive (83%\u201394%) but not specific (34%\u201349%) for pathologic changes. Fibrillation potentials were 65%\u201374% sensitive and 58%\u201381% specific for inflammation, necrosis, splitting, or vacuolar changes. The absence of fibrillation potentials had high negative predictive value (82%\u201393%) for inflammation, splitting, or vacuolar changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      Fibrillation potentials and short\u2010duration MUPs predict pathologic changes of muscle fiber necrosis, splitting, and\/or vacuolar changes (as seen with inflammatory myopathies and muscular dystrophies). Absence of fibrillation potentials suggests other myopathologic changes (e.g., congenital myopathy).\n                      <jats:italic>Muscle Nerve<\/jats:italic>\n                      <jats:bold>59<\/jats:bold>\n                      :315\u2013320, 2019\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.26381","type":"journal-article","created":{"date-parts":[[2018,11,10]],"date-time":"2018-11-10T10:44:19Z","timestamp":1541846659000},"page":"315-320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Needle electromyography and histopathologic correlation in myopathies"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3919-7408","authenticated-orcid":false,"given":"Ugur","family":"Sener","sequence":"first","affiliation":[{"name":"Mayo Clinic Neurology Department  4500 San Pablo Road South, Jacksonville Florida, 32224 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Martinez\u2010Thompson","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruple S.","family":"Laughlin","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot L.","family":"Dimberg","sequence":"additional","affiliation":[{"name":"Mayo Clinic Neurology Department  4500 San Pablo Road South, Jacksonville Florida, 32224 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devon I.","family":"Rubin","sequence":"additional","affiliation":[{"name":"Mayo Clinic Neurology Department  4500 San Pablo Road South, Jacksonville Florida, 32224 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2011.12.007"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2011.12.009"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.069211"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2012.08.017"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2012.06.006"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(71)90209-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880050403"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X1988000200006"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02361435"},{"key":"e_1_2_7_11_1","first-page":"37","article-title":"A correlative study of quantitative EMG and biopsy findings in 31 patients with myopathies","author":"Dardiotis E","year":"2011","journal-title":"Acta Myol"},{"key":"e_1_2_7_12_1","first-page":"51","article-title":"The diagnostic value of EMG compared with that of muscle biopsy in 71 myopathies","volume":"2","author":"Micaglio GF","year":"1980","journal-title":"Acta Neurol"},{"issue":"10","key":"e_1_2_7_13_1","first-page":"655","article-title":"Correlative findings by electromyography and muscle biopsy in neuromuscular disorders","volume":"47","author":"Schwartz RA","year":"1966","journal-title":"Arch Phys Med Rehab"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2010.12.024"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00131402-199912000-00002"},{"issue":"3","key":"e_1_2_7_16_1","first-page":"328","article-title":"Electromyography in benign congenital myopathies","volume":"16","author":"Dietzen CJ","year":"1993","journal-title":"Muscle Nerve"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880170410"},{"key":"e_1_2_7_18_1","first-page":"118","article-title":"Electromyographic and histologic paraspinal abnormalities in polymyositis\/dermatomyositis","volume":"62","author":"Mitz M","year":"1981","journal-title":"Arch Phys Med Rehabil"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00839"}],"container-title":["Muscle &amp; 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