{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:58:52Z","timestamp":1790366332501,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T00:00:00Z","timestamp":1545782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"MGH ALS Therapy Fund"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Introduction<\/jats:italic>\n                    : RNS60 is a novel immune\u2010modulatory agent that has shown neuroprotective effects in amytrophic lateral sclerosis (ALS) preclinical models. RNS60 is administered by weekly intravenous infusion and daily nebulization. The objective of this pilot open\u2010label trial was to test the feasibility, safety, and tolerability of long\u2010term RNS60 administration in ALS patients.\n                    <jats:italic>Methods<\/jats:italic>\n                    : The planned treatment duration was 23 weeks and the primary outcomes were safety and tolerability. Secondary outcomes included PBR28 positron emission tomography (PET) imaging and plasma biomarkers of inflammation.\n                    <jats:italic>Results<\/jats:italic>\n                    : Sixteen participants with ALS received RNS60 and 13 (81%) completed 23 weeks of RNS60 treatment. There were no serious adverse events and no participants withdrew from the trial due to drug\u2010related adverse events. There were no significant changes in the biomarkers.\n                    <jats:italic>Discussion<\/jats:italic>\n                    : Long\u2010term RNS60 administration was safe and well\u2010tolerated. A large, multicenter, phase II trial of RNS60 is currently enrolling participants to test the effects of RNS60 on ALS biomarkers and disease progression.\n                    <jats:italic>Muscle Nerve<\/jats:italic>\n                    <jats:bold>59<\/jats:bold>\n                    :303\u2013308, 2019\n                  <\/jats:p>","DOI":"10.1002\/mus.26385","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T12:19:01Z","timestamp":1542716341000},"page":"303-308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["A pilot trial of RNS60 in amyotrophic lateral sclerosis"],"prefix":"10.1002","volume":"59","author":[{"given":"Sabrina","family":"Paganoni","sequence":"first","affiliation":[{"name":"Neurological Clinical Research Institute Massachusetts General Hospital  165 Cambridge Street, Suite 600, Boston Massachusetts 02114 USA"},{"name":"Spaulding Rehabilitation Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad J.","family":"Alshikho","sequence":"additional","affiliation":[{"name":"Neurological Clinical Research Institute Massachusetts General Hospital  165 Cambridge Street, Suite 600, Boston Massachusetts 02114 USA"},{"name":"Athinoula A. 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