{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T13:53:18Z","timestamp":1725976398477},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T00:00:00Z","timestamp":1547164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL085800","R21 AR055704"],"award-info":[{"award-number":["R01 HL085800","R21 AR055704"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Statins reduce cardiovascular disease risk and are generally well tolerated, yet up to 0.5% of statin\u2010treated patients develop incapacitating muscle symptoms including rhabdomyolysis. Our objective was to identify clinical factors related to statin\u2010associated muscle symptoms (SAMS). <jats:italic>Methods<\/jats:italic>: Clinical and laboratory characteristics were evaluated in 748 statin\u2010treated Caucasians (634 with SAMS and 114 statin\u2010tolerant controls). Information was collected on statin type, concomitant drug therapies, muscle symptom history, comorbidities, and family history. Logistic regression was used to identify associations. <jats:italic>Results<\/jats:italic>: Individuals with SAMS were 3.6 times (odds ratio [OR] 3.60, 95% confidence interval [CI] 2.08\u20106.22) more likely than statin\u2010tolerant controls to have a family history of heart disease. Additional associations included obesity (OR 3.08, 95% CI 1.18, 8.05), hypertension (OR 2.24, 95% CI 1.33, 3.77), smoking (OR 2.08, 95% CI 1.16, 3.74), and statin type. <jats:italic>Discussion<\/jats:italic>: Careful medical monitoring of statin\u2010treated patients with the associated coexisting conditions may ultimately reduce muscle symptoms and lead to improved compliance.  <jats:italic>Muscle Nerve<\/jats:italic> 59:537\u2013537, 2019<\/jats:p>","DOI":"10.1002\/mus.26397","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T07:53:23Z","timestamp":1544774003000},"page":"537-543","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinical features related to statin\u2010associated muscle symptoms"],"prefix":"10.1002","volume":"59","author":[{"given":"Heather M.","family":"Ochs\u2010Balcom","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Environmental Health School of Public Health and Health Professions, University at Buffalo  270 Farber Hall, Buffalo New York 14214\u20108001 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ly Minh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University at Buffalo  Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changxing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Biostatistics School of Public Health and Health Professions, University at Buffalo  Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Isackson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jacobs School of Medicine and Biomedical Sciences, University at Buffalo  Buffalo New York USA"},{"name":"Kaleida Health Laboratories  Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmine A.","family":"Luzum","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy University of Michigan College of Pharmacy  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph P.","family":"Kitzmiller","sequence":"additional","affiliation":[{"name":"Center for Pharmacogenomics The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Tarnopolsky","sequence":"additional","affiliation":[{"name":"Department of Pediatrics McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Weisman","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Christopher\u2010Stine","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology Johns Hopkins School of Medicine, Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Peltier","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical College of Wisconsin  Milwaukee Wisconsin USA"},{"name":"Department of Medicine Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L.","family":"Wortmann","sequence":"additional","affiliation":[{"name":"Department of Medicine The Geisel School of Medicine, Dartmouth\u2010Hitchcock Medical Center  Lebanon New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgirene D.","family":"Vladutiu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jacobs School of Medicine and Biomedical Sciences, University at Buffalo  Buffalo New York USA"},{"name":"Department of Neurology Jacobs School of Medicine and Biomedical Sciences, University at Buffalo  Buffalo New York USA"},{"name":"Department of Pathology &amp; 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