{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:11:18Z","timestamp":1787847078829,"version":"build-2784847793"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T00:00:00Z","timestamp":1548288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Paul D. Wellstone Muscular Dystrophy Cooperative Research Centers","award":["NIH U54 NS053672"],"award-info":[{"award-number":["NIH U54 NS053672"]}]},{"name":"Abboud Cardiovascular Research Center","award":["NIH 5T32HL007121-42"],"award-info":[{"award-number":["NIH 5T32HL007121-42"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Patients with Duchenne muscular dystrophy (DMD) exhibit low bone mineral density and increased fracture risk. Because glucocorticoid therapy results in delayed puberty and short stature, it is important to account for delayed skeletal development when interpreting patients\u2019 bone mineral density.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twelve glucocorticoid\u2010treated patients with DMD were evaluated by dual x\u2010ray absorptiometry scans and wrist x\u2010rays to estimate bone density and bone age, respectively. Z\u2010scores were determined on the basis of chronological age. Each patient was assigned a \u201ccorrected\u201d birth date that was calculated according to bone age, and a bone\u2010age\u2010corrected z\u2010score was determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Z\u2010scores adjusted for chronological age were lower than those adjusted for bone age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>We suggest the use of bone age as an alternative to chronological age for analysis of bone mineral density in glucocorticoid\u2010treated patients with DMD. Additional research is required to determine the optimal method to predict fracture risk in this patient group. <jats:italic>Muscle Nerve<\/jats:italic> 59:422\u2013425, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26413","type":"journal-article","created":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T12:33:11Z","timestamp":1547296391000},"page":"422-425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Use of bone age for evaluating bone density in patients with Duchenne muscular dystrophy: A preliminary report"],"prefix":"10.1002","volume":"59","author":[{"given":"Asma","family":"Al\u2010Zougbi","sequence":"first","affiliation":[{"name":"Department of Medicine University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine D.","family":"Mathews","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Iowa  Iowa City Iowa USA"},{"name":"Department of Neurology University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Shibli\u2010Rahhal","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2044"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.L.01577"},{"issue":"5","key":"e_1_2_7_4_1","article-title":"Corticosteroids for the treatment of Duchenne muscular dystrophy","author":"Matthews E","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32160-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(01)00307-8"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2004.09.009"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30025-5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3096"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2012.06.354"},{"issue":"1","key":"e_1_2_7_11_1","article-title":"Improved DEXA methodology for bone mass assessment in boys with Duchenne muscular dystrophy","volume":"64","author":"King WM","year":"2005","journal-title":"Neurology."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1385\/JCD:8:1:048"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1385\/JCD:7:1:17"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.109601"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1992.tb08563.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30024-3"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2004.tb00508.x"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.26413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.26413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T03:08:41Z","timestamp":1694401721000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.26413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,24]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1002\/mus.26413"],"URL":"https:\/\/doi.org\/10.1002\/mus.26413","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,24]]},"assertion":[{"value":"2018-02-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}