{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:53:21Z","timestamp":1790045601166,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T00:00:00Z","timestamp":1548115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["SALUD\u20102012\u201001\u2010180058"],"award-info":[{"award-number":["SALUD\u20102012\u201001\u2010180058"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Introduction<\/jats:italic>\n                    : Patients with Duchenne muscular dystrophy (DMD) demonstrate decreased bone mineral density (BD). It is not clear which factors exert the greatest impact on BD loss in these patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    : In 63 patients with DMD, serum cytokines (interleukin [IL]\u20101, IL\u20106, and tumor necrosis factor\u2010beta [TNF\u2010\u03b2]), C\u2010reactive protein (CRP), creatine kinase (CK), muscle function (by Vignos scale), body composition, and total BD (the latter 2 measured by dual\u2010energy X\u2010ray absorptiometry, or DEXA) were determined.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    : The main factors associated with BD loss were muscle function (34.0%; \u03b2 = \u22120.139;\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.023) and age (36.7%; \u03b2 = \u22120.151;\n                    <jats:italic>P =<\/jats:italic>\n                    0.004). Cytokines, CRP, body fat mass, and CK did not contribute to BD loss.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Discussion<\/jats:italic>\n                    : Muscle function and age contribute to BD loss in DMD. We propose that a cut\u2010off of at least 6 points for the Vignos scale and at least 10.5 years of age predict a\n                    <jats:italic>Z<\/jats:italic>\n                    \u2010score of less than or equal to \u22122.0.\n                    <jats:italic>Muscle Nerve<\/jats:italic>\n                    59:417\u2013421, 2019\n                  <\/jats:p>","DOI":"10.1002\/mus.26416","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T03:05:18Z","timestamp":1547003118000},"page":"417-421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Muscle function and age are associated with loss of bone mineral density in Duchenne muscular dystrophy"],"prefix":"10.1002","volume":"59","author":[{"given":"Oriana","family":"Del Roc\u00edo Cruz\u2010Guzm\u00e1n","sequence":"first","affiliation":[{"name":"Laboratorio de Nutrici\u00f3n Molecular, Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n, Hospital de Pediatr\u00eda Centro M\u00e9dico Nacional Siglo XXI\u2010IMSS Av. Cuauht\u00e9moc No. 330, Col. Doctores, Delegaci\u00f3n, Cuauht\u00e9moc, 06725 Ciudad de M\u00e9xico M\u00e9xico"},{"name":"Laboratorio de Biomembranas, Departamento de Bioqu\u00edmica, Escuela Nacional de Ciencias Biol\u00f3gicas Instituto Polit\u00e9cnico Nacional Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maricela","family":"Rodr\u00edguez\u2010Cruz","sequence":"additional","affiliation":[{"name":"Laboratorio de Nutrici\u00f3n Molecular, Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n, Hospital de Pediatr\u00eda Centro M\u00e9dico Nacional Siglo XXI\u2010IMSS Av. Cuauht\u00e9moc No. 330, Col. Doctores, Delegaci\u00f3n, Cuauht\u00e9moc, 06725 Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Almeida\u2010Becerril","sequence":"additional","affiliation":[{"name":"Laboratorio de Nutrici\u00f3n Molecular, Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n, Hospital de Pediatr\u00eda Centro M\u00e9dico Nacional Siglo XXI\u2010IMSS Av. Cuauht\u00e9moc No. 330, Col. Doctores, Delegaci\u00f3n, Cuauht\u00e9moc, 06725 Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Maldonado\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratorio de Nutrici\u00f3n Molecular, Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n, Hospital de Pediatr\u00eda Centro M\u00e9dico Nacional Siglo XXI\u2010IMSS Av. Cuauht\u00e9moc No. 330, Col. Doctores, Delegaci\u00f3n, Cuauht\u00e9moc, 06725 Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Wong","family":"Baeza","sequence":"additional","affiliation":[{"name":"Laboratorio de Biomembranas, Departamento de Bioqu\u00edmica, Escuela Nacional de Ciencias Biol\u00f3gicas Instituto Polit\u00e9cnico Nacional Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.12.046"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/bonekey.2012.5"},{"key":"e_1_2_6_4_1","first-page":"252","article-title":"Bone health in children with Duchenne muscular dystrophy: a review","volume":"5","author":"Perera N","year":"2015","journal-title":"Pediatr Ther"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12018-014-9156-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2006.09.016"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/540370"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/46.10.1703"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e3181a5a24f"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.410"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12018-013-9151-4"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/891972"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2011.06.750"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2012.03.006"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R109.041087"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5484.1504"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01658"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.116297"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533615586202"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1993.tb07925.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/867273"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(60)90105-3"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008526-200610000-00005"},{"key":"e_1_2_6_24_1","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195171693.001.0001","volume-title":"Principles of nutritional assessment","author":"Gibson R","year":"2005"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2014.01.003"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2007.05.008"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/76.6.1416"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.10.1594"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-200001000-00016"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70271-6"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.5812\/ijem.25542v2"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-007-9070-0"},{"key":"e_1_2_6_33_1","first-page":"8","article-title":"Suzuki K, Nieman DC. 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