{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:25:45Z","timestamp":1789982745578,"version":"4.0.1"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K01HD084690\u201002"],"award-info":[{"award-number":["K01HD084690\u201002"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002426","name":"Fondazione Telethon","doi-asserted-by":"publisher","award":["GSP13002"],"award-info":[{"award-number":["GSP13002"]}],"id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000894","name":"Spinal Muscular Atrophy Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000894","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: The aim of the study was to assess 12\u2009month changes in upper limb function in patients affected by spinal muscular atrophy type 2 and 3. <jats:italic>Methods<\/jats:italic>: Longitudinal 12\u2009month data was collected in 114 patients, 60 type 2 and 54 type 3, using the Revised Upper Limb Module. <jats:italic>Results<\/jats:italic>: The 12\u2009month changes ranged between \u20107 and 9 (mean: \u20100.41; SD: 2.93). The mean changes were not significantly different between the three spinal muscular atrophy groups (\u20100.45 in type 2, \u20100.23 in non\u2010ambulant type 3 and \u20100.34 in ambulant type 3, p\u2009=\u20090.96) and the relationship between 12\u2009month change and age classes was not significantly different among the three types of SMA patients. <jats:italic>Discussion<\/jats:italic>: Our results confirm that the Module explores a wide range of functional abilities and can be used in ambulant and non\u2010ambulant patients of different ages in conjunction with other functional scales. <jats:italic>Muscle Nerve<\/jats:italic> 59:426\u2013430, 2019<\/jats:p>","DOI":"10.1002\/mus.26419","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T23:32:30Z","timestamp":1548372750000},"page":"426-430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["Revised upper limb module for spinal muscular atrophy: 12\u2009month changes"],"prefix":"10.1002","volume":"59","author":[{"given":"Maria Carmela","family":"Pera","sequence":"first","affiliation":[{"name":"Paediatric Neurology and Centro Clinico Nemo Catholic University and Policlinico Gemelli, Fondazione Policlinico Universitario Agostino Gemelli IRCSS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Coratti","sequence":"additional","affiliation":[{"name":"Paediatric Neurology and Centro Clinico Nemo Catholic University and Policlinico Gemelli, Fondazione Policlinico Universitario Agostino Gemelli IRCSS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena S.","family":"Mazzone","sequence":"additional","affiliation":[{"name":"Paediatric Neurology and Centro Clinico Nemo Catholic University and Policlinico Gemelli, Fondazione Policlinico Universitario Agostino Gemelli IRCSS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Montes","sequence":"additional","affiliation":[{"name":"Departments of Rehabilitation and Regenerative Medicine Columbia University Medical Center  New York USA"},{"name":"Departments of Neurology Columbia University Medical Center  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariacristina","family":"Scoto","sequence":"additional","affiliation":[{"name":"Dubowitz Neuromuscular Centre and NIHR Great Ormond Street Hospital Biomedical Research Centre Institute of Child Health &amp; Great Ormond Street Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"De Sanctis","sequence":"additional","affiliation":[{"name":"Paediatric Neurology and Centro Clinico Nemo Catholic University and Policlinico Gemelli, Fondazione Policlinico Universitario Agostino Gemelli IRCSS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Main","sequence":"additional","affiliation":[{"name":"Dubowitz Neuromuscular Centre and NIHR Great Ormond Street Hospital Biomedical Research Centre Institute of Child Health &amp; Great Ormond Street Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Mayhew","sequence":"additional","affiliation":[{"name":"John Walton Muscular Dystrophy Research Centre Newcastle University  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Muni Lofra","sequence":"additional","affiliation":[{"name":"John Walton Muscular Dystrophy Research Centre Newcastle University  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Dunaway Young","sequence":"additional","affiliation":[{"name":"Departments of Rehabilitation and Regenerative Medicine Columbia University Medical Center  New York USA"},{"name":"Departments of Neurology Columbia University Medical Center  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan M.","family":"Glanzman","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy The Children's Hospital of Philadelphia  Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Duong","sequence":"additional","affiliation":[{"name":"Department of Neurology Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8841-2613","authenticated-orcid":false,"given":"Amy","family":"Pasternak","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Children's Hospital, Harvard Medical School  Boston MA USA"},{"name":"Department of Physical Therapy and Occupational Therapy Boston Children's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Ramsey","sequence":"additional","affiliation":[{"name":"Dubowitz Neuromuscular Centre and NIHR Great Ormond Street Hospital Biomedical Research Centre Institute of Child Health &amp; Great Ormond Street Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basil","family":"Darras","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Children's Hospital, Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Day","sequence":"additional","affiliation":[{"name":"Department of Neurology Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"Finkel","sequence":"additional","affiliation":[{"name":"Nemours Children's Hospital University of Central Florida College of Medicine  Orlando USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darryl C.","family":"De Vivo","sequence":"additional","affiliation":[{"name":"Departments of Neurology Columbia University Medical Center  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Pia","family":"Sormani","sequence":"additional","affiliation":[{"name":"Department of Health Sciences (DISSAL) Section of Biostatistics, University of Genova  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Bovis","sequence":"additional","affiliation":[{"name":"Department of Health Sciences (DISSAL) Section of Biostatistics, University of Genova  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Straub","sequence":"additional","affiliation":[{"name":"John Walton Muscular Dystrophy Research Centre Newcastle University  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Muntoni","sequence":"additional","affiliation":[{"name":"Dubowitz Neuromuscular Centre and NIHR Great Ormond Street Hospital Biomedical Research Centre Institute of Child Health &amp; 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