{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T01:28:16Z","timestamp":1794360496437,"version":"4.9.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,23]],"date-time":"2019-02-23T00:00:00Z","timestamp":1550880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005202","name":"Muscular Dystrophy Association","doi-asserted-by":"publisher","award":["266053"],"award-info":[{"award-number":["266053"]}],"id":[{"id":"10.13039\/100005202","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction:<\/jats:italic> Glucocorticosteroids (GC) are effective in slowing weakness in boys with Duchenne muscular dystrophy (DMD). <jats:italic>Methods:<\/jats:italic> This is a multisite, 1\u2010year, open\u2010label trial of twice\u2010weekly prednisolone (5\u2009mg\/kg\/dose) in infants\/young boys (0.4\u20132.4\u2009years) with DMD. We compared changes in Bayley III Scales of Infant Development (Bayley\u2010III) with untreated boys followed for 1\u2009year (historical control cohort [HCC]). Twenty\u2010three of 25 participants completed the study. <jats:italic>Results:<\/jats:italic> Treated boys gained an average of 0.5 points on the Bayley\u2010III gross motor scaled score (GMSS) compared with the HCC who, on average, declined 1.3 points (<jats:italic>P<\/jats:italic>\u2009=\u20090.03). All boys maintained linear growth, and none developed Cushingoid features. Excessive weight gain occurred in 13 of 23 (56%) boys. <jats:italic>Discussion:<\/jats:italic> This study provides evidence that twice\u2010weekly GC is well tolerated in infants and young boys with DMD and improves GMSS. Excessive weight gain is a potential risk. Longer follow\u2010up is required to determine whether early GC initiation is feasible in most infants\/boys with DMD. <jats:italic>Muscle Nerve<\/jats:italic> 59:650\u2013657, 2019<\/jats:p>","DOI":"10.1002\/mus.26441","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T08:05:19Z","timestamp":1549008319000},"page":"650-657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Twice\u2010weekly glucocorticosteroids in infants and young boys with Duchenne muscular dystrophy"],"prefix":"10.1002","volume":"59","author":[{"given":"Anne M.","family":"Connolly","sequence":"first","affiliation":[{"name":"Department of Neurology Washington University School of Medicine in Saint Louis  St Louis Missouri USA 63110"},{"name":"Department of Pediatrics Washington University School of Medicine in Saint Louis  St Louis Missouri 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