{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:29:38Z","timestamp":1789655378046,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T00:00:00Z","timestamp":1551830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction. Approximately 10%\u201315% of MG patients have juvenile (&lt;18\u2009years of age) onset. We aimed to assess the clinical course, outcome, and subjectively perceived health status of a cohort of juvenile MG patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective analysis of medical records of 101 patients followed by a cross\u2010sectional questionnaire study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of patients was 12.8\u2009years at onset and 13.7\u2009years at diagnosis. Ninety percent of the patients were seropositive. Over 40% of the patients were treated with immunosuppression and over 80% underwent thymectomy. The mean Myathenia Gravis Activities of Daily Living (MG\u2010ADL) scale score was 2.48. At last follow\u2010up, 30.9% of patients were in complete, stable remission; 77.8% perceived their health as good.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The treatment outcome for juvenile MG is favorable, with a marked reduction of symptoms and good day\u2010to\u2010day activity achieved for most patients. <jats:italic>Muscle Nerve<\/jats:italic> 59:549\u2013549, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26445","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T06:43:16Z","timestamp":1549608196000},"page":"549-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Treatment outcome in juvenile\u2010onset myasthenia gravis"],"prefix":"10.1002","volume":"59","author":[{"given":"Aleksandra","family":"Jastrz\u0119bska","sequence":"first","affiliation":[{"name":"Department of Neurology Medical University of Warsaw  1A Banacha Street, 02\u2010097, Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi\u0142osz","family":"Jastrz\u0119bski","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Internal Medicine Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Ryniewicz","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Warsaw  1A Banacha Street, 02\u2010097, Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kostera\u2010Pruszczyk","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Warsaw  1A Banacha Street, 02\u2010097, Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.26.11.1054"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CND.0b013e318253a48e"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2016.09.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000279334"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20950"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002790"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.7.1487"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5215-2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32833c32af"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(98)00077-7"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01959485"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb14162.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.30.7.732"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2008.02176.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1602678"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880150616"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000285"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1254.043"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.6.1153"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-872879"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.537"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050135"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22140"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.7.1208"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2013.09.013"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602489"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1971.00490050019001"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.74.869.139"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128072-200002030-00001"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-013-3438-x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2008.05.032"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000267694.45244.f4"}],"container-title":["Muscle &amp; 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