{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:27:54Z","timestamp":1791912474663,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T00:00:00Z","timestamp":1552003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006396","name":"Alexion Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006396","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Introduction<\/jats:italic>\n                    : Eculizumab is effective and well tolerated in patients with antiacetylcholine receptor antibody\u2010positive refractory generalized myasthenia gravis (gMG; REGAIN; NCT01997229). We report an interim analysis of an open\u2010label extension of REGAIN, evaluating eculizumab's long\u2010term safety and efficacy.\n                    <jats:italic>Methods<\/jats:italic>\n                    : Eculizumab (1,200\u2009mg every 2\u2009weeks for 22.7\u2009months [median]) was administered to 117 patients.\n                    <jats:italic>Results<\/jats:italic>\n                    : The safety profile of eculizumab was consistent with REGAIN; no cases of meningococcal infection were reported during the interim analysis period. Myasthenia gravis exacerbation rate was reduced by 75% from the year before REGAIN (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Improvements with eculizumab in activities of daily living, muscle strength, functional ability, and quality of life in REGAIN were maintained through 3\u2009years; 56% of patients achieved minimal manifestations or pharmacological remission. Patients who had received placebo during REGAIN experienced rapid and sustained improvements during open\u2010label eculizumab (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.0001).\n                    <jats:italic>Discussion<\/jats:italic>\n                    : These findings provide evidence for the long\u2010term safety and sustained efficacy of eculizumab for refractory gMG.\n                    <jats:italic>Muscle Nerve<\/jats:italic>\n                    2019\n                  <\/jats:p>","DOI":"10.1002\/mus.26447","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T23:50:31Z","timestamp":1550188231000},"page":"14-24","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":245,"title":["Long\u2010term safety and efficacy of eculizumab in generalized myasthenia gravis"],"prefix":"10.1002","volume":"60","author":[{"given":"Srikanth","family":"Muppidi","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosciences Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimiaki","family":"Utsugisawa","sequence":"additional","affiliation":[{"name":"Department of Neurology Hanamaki General Hospital  Hanamaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Benatar","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Murai","sequence":"additional","affiliation":[{"name":"Department of Neurology International University of Health and Welfare  Narita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard 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