{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T08:15:39Z","timestamp":1783412139001,"version":"3.54.6"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,24]],"date-time":"2019-03-24T00:00:00Z","timestamp":1553385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT)\/ Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior (MCTES) through Fundos do Or\u00e7amento de Estado","award":["UID\/BIM\/50005\/2019"],"award-info":[{"award-number":["UID\/BIM\/50005\/2019"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Fasciculations are a marker for the diagnosis of amyotrophic lateral sclerosis (ALS) and reflect increased lower motor neuron (LMN) excitability. <jats:italic>Methods<\/jats:italic>: We investigated modulation of fasciculation frequency in the first dorsal interosseous (FDI) muscle of the right hand following peripheral sensory nerve electrical stimulation, and vibration over the muscle\u2010tendon region (50 and 100\u2009H<jats:sc>z<\/jats:sc>), in patients with ALS, spinal muscular atrophy, and benign fasciculation syndrome. FDI muscles of ALS patients were classified by the presence or absence of neurogenic changes on needle electromyography. <jats:italic>Results<\/jats:italic>: Both sensory nerve electrical stimulation and vibration significantly increased the frequency of fasciculations in neurogenic FDI muscles of ALS patients, but not in the remaining groups. <jats:italic>Discussion<\/jats:italic>: Our results favour increased excitability of LMNs when affected by the disease process in ALS. We found that some fasciculations originating in these neurons in ALS are susceptible to modulation by sensory input. <jats:italic>Muscle Nerve<\/jats:italic> 59:688\u2013693, 2019<\/jats:p>","DOI":"10.1002\/mus.26456","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T08:58:50Z","timestamp":1551257930000},"page":"688-693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sensory modulation of fasciculation discharge frequency"],"prefix":"10.1002","volume":"59","author":[{"given":"Mamede","family":"de Carvalho","sequence":"first","affiliation":[{"name":"Instituto de Fisiologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa  Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Turkman","sequence":"additional","affiliation":[{"name":"Centro de Estat\u00edstica e Aplica\u00e7\u00f5es, Faculty of Sciences University of Lisbon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Swash","sequence":"additional","affiliation":[{"name":"Instituto de Fisiologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa  Portugal"},{"name":"Departments of Neurology and Neuroscience Barts and the London School of Medicine, Queen Mary University of London  United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-304545"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-315574"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/61.3.311"},{"key":"e_1_2_7_5_1","first-page":"226","article-title":"Modulation of fasciculation frequency in amyotrophic lateral sclerosis","volume":"87","author":"Carvalho M","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.09.143"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2016.02.011"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1981.sp013880"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018464"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05834.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1969.sp008968"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.5.929"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1981.sp013598"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00228968"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1970.sp009090"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.11.2148"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080557"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2010.02188.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.149286"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-07-02534.2000"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880130612"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.33.1.40"},{"key":"e_1_2_7_24_1","unstructured":"Hagbarth K\u2010E. The effect of muscle vibration in normal man and in patients with motor disorders. In:DesmedtJE editor (ed). New Developments in Electromyography and Clinical Neurophysiology (Basel): Karger;1973. vol.3."},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012567"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000178106.68569.7e"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90255-3"},{"key":"e_1_2_7_28_1","volume-title":"The integrative action of the nervous system","author":"Sherrington C.","year":"1906"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12576-016-0484-x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-302315"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2014.07.029"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.26456","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.26456","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.26456","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.26456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T07:17:19Z","timestamp":1694157439000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.26456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,24]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1002\/mus.26456"],"URL":"https:\/\/doi.org\/10.1002\/mus.26456","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,24]]},"assertion":[{"value":"2018-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}