{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:25Z","timestamp":1786978225682,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,3,24]],"date-time":"2019-03-24T00:00:00Z","timestamp":1553385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000659","name":"Research Trainees Coordinating Centre","doi-asserted-by":"publisher","award":["SRF\u20102012\u201005\u2010119"],"award-info":[{"award-number":["SRF\u20102012\u201005\u2010119"]}],"id":[{"id":"10.13039\/501100000659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Studies of prognosis for surgery and corticosteroid injection for carpal tunnel syndrome (CTS) have considered only a limited range of explanatory variables for outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were prospectively collected on patient\u2010reported symptoms, physical and psychological functioning, comorbidity, and quality of life at baseline and every 6\u2009months for up to 2\u2009years. Outcomes were patient\u2010rated change over a 6\u2010month period and symptom\u2010severity score at 18\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 754 patients with CTS completed baseline questionnaires, and 626 (83%) completed follow\u2010up to 18\u2009months. Multivariable modeling identified, independent of symptom severity at outset, higher health utility, fewer comorbidities, and lower anxiety as significant predictors of better outcome from surgery. In patients treated by steroid injection, independent of symptom severity at outset, shorter duration of symptoms and having no prior injection were significant predictors of better outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      These multivariable models of outcome may inform shared decision making about treatment for CTS.\n                      <jats:italic>Muscle Nerve<\/jats:italic>\n                      , 2019\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.26459","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T03:13:40Z","timestamp":1551323620000},"page":"32-40","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Prognostic factors for response to treatment by corticosteroid injection or surgery in carpal tunnel syndrome (palms study): A prospective multicenter cohort study"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0525-1282","authenticated-orcid":false,"given":"Christina","family":"Jerosch\u2010Herold","sequence":"first","affiliation":[{"name":"School of Health Sciences, Faculty of Medicine and Health Sciences University of East Anglia  Norwich, NR4 7TJ United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Shepstone","sequence":"additional","affiliation":[{"name":"Norwich Medical School University of East Anglia  Norwich United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Houghton","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Faculty of Medicine and Health Sciences University of East Anglia  Norwich, NR4 7TJ United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward C. F.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Cambridge Centre for Health Services Research, Institute of Public Health University of Cambridge  Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Blake","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology Norfolk and Norwich University Hospital  Norwich United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30231-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g6437"},{"issue":"2","key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0363-5023(99)70014-6","article-title":"Symptoms, disability, and quality of life in patients with carpal tunnel syndrome","volume":"24","author":"Atroshi I","year":"1999","journal-title":"J Hand Surg Am"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-017732"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23725"},{"key":"e_1_2_6_7_1","first-page":"CD001554","article-title":"Local corticosteroid injection for carpal tunnel syndrome","volume":"2","author":"Marshall S","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2010.03.023"},{"issue":"17","key":"e_1_2_6_9_1","first-page":"1","article-title":"Is surgical intervention more effective than nonsurgical treatment for carpal tunnel syndrome? 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