{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:23:03Z","timestamp":1784179383672,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T00:00:00Z","timestamp":1560384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hereditary transthyretin (hATTR) amyloidosis is a progressive, degenerative disease, with peripheral neuropathy, cardiomyopathy, and other clinical manifestations. In this study we examine the impact of hATTR amyloidosis on quality of life (QOL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Neuropathy\u2010specific QOL, measured with the Norfolk QOL\u2010Diabetic Neuropathy questionnaire, was compared between patients with hATTR amyloidosis and patients with type 2 diabetes, whereas generic QOL, measured with the 36\u2010item Short Form Health Survey version 2 (SF\u201036v2), was compared between patients with hATTR amyloidosis, the general population, and patients with chronic diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Neuropathy\u2010specific QOL for patients with hATTR amyloidosis was nearly equivalent to that of patients with type 2 diabetes with diabetic neuropathy accompanied by a history of ulceration, gangrene, or amputation. Generic QOL was worse than that seen in the general population, with physical functioning worse than that for patients with multiple sclerosis and congestive heart failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Patients with hATTR amyloidosis show significant burden on QOL, particularly in physical functioning. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>60<\/jats:bold>: 169\u2013175, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26515","type":"journal-article","created":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T06:30:07Z","timestamp":1557988207000},"page":"169-175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Burden of hereditary transthyretin amyloidosis on quality of life"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4600-259X","authenticated-orcid":false,"given":"Aaron","family":"Yarlas","sequence":"first","affiliation":[{"name":"Optum  1301 Atwood Avenue, Suite 311N, Johnston Rhode Island 02919 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morie A.","family":"Gertz","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel R.","family":"Dasgupta","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Obici","sequence":"additional","affiliation":[{"name":"Amyloidosis Research and Treatment Center Fondazione IRCCS Policlinico S. Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Pollock","sequence":"additional","affiliation":[{"name":"Akcea Therapeutics  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Ackermann","sequence":"additional","affiliation":[{"name":"Akcea Therapeutics  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Lovley","sequence":"additional","affiliation":[{"name":"Optum  1301 Atwood Avenue, Suite 311N, Johnston Rhode Island 02919 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asia Sikora","family":"Kessler","sequence":"additional","affiliation":[{"name":"Optum  1301 Atwood Avenue, Suite 311N, Johnston Rhode Island 02919 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj A.","family":"Patel","sequence":"additional","affiliation":[{"name":"Kantar Health  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle K.","family":"White","sequence":"additional","affiliation":[{"name":"Optum  1301 Atwood Avenue, Suite 311N, Johnston Rhode Island 02919 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer D.","family":"Guthrie","sequence":"additional","affiliation":[{"name":"Biopharma Strategic Consulting  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199709253371306"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/msj.21352"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-072611-130030"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-31"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079589"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2015.1068949"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.03.596"},{"key":"e_1_2_6_9_1","first-page":"S107","article-title":"Hereditary ATTR amyloidosis: burden of illness and diagnostic challenges","volume":"23","author":"Gertz MA","year":"2017","journal-title":"Am J Manag Care"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.09.075"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-018-0106-z"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-10-S1-O28"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25257"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns5.12059"},{"key":"e_1_2_6_15_1","first-page":"88","volume-title":"Amyloid and amyloidosis","author":"Glenner G","year":"1980"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2015.04.001"},{"key":"e_1_2_6_17_1","volume-title":"User's manual for the SF\u201036v2 Health Survey","author":"Maruish ME","year":"2011"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2005.7.497"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(89)90005-6"},{"key":"e_1_2_6_20_1","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen J","year":"1988"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-315262"}],"container-title":["Muscle &amp; 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