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Although muscle atrophy occurs very rapidly after nerve injury, the effect of 4\u2010AP on muscle atrophy and intrinsic muscle contractile function is largely unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Mice were assigned to sciatic nerve crush injury and no\u2010injury groups and were followed for 3, 7, and 14 days with\/without 4\u2010AP or saline treatment. Morphological, functional, and transcriptional properties of skeletal muscle were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In addition to improving <jats:italic>in vivo<\/jats:italic> function, 4\u2010AP significantly reduced muscle atrophy with increased muscle fiber diameter and contractile force. Reduced muscle atrophy was associated with attenuated expression of atrophy\u2010related genes and increased expression of proliferating stem cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These findings provide new insights into the potential therapeutic benefits of 4\u2010AP against nerve injury\u2010induced muscle atrophy and dysfunction. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>60<\/jats:bold>: 192\u2013201, 2019<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26516","type":"journal-article","created":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T06:40:04Z","timestamp":1557988804000},"page":"192-201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["4\u2010Aminopyridine attenuates muscle atrophy after sciatic nerve crush injury in mice"],"prefix":"10.1002","volume":"60","author":[{"given":"Li","family":"Yue","sequence":"first","affiliation":[{"name":"Department of Orthopaedics The Warren Alpert Medical School of Brown University\/Rhode Island Hospital  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Talukder","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Center for Orthopaedics and Translational Science The Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center  500 University Drive, Mail Code H089, Hershey Pennsylvania 17033 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anagha","family":"Gurjar","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Center for Orthopaedics and Translational Science The Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center  500 University Drive, Mail Code H089, Hershey Pennsylvania 17033 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Il","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Hanyang University Guri Hospital  South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Noble","sequence":"additional","affiliation":[{"name":"Department of Biomedical Genetics The University of Rochester Medical Center Rochester  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert T.","family":"Dirksen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Physiology The University of Rochester Medical Center Rochester  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Chakkalakal","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology and Biomedical Engineering The University of Rochester Medical Center Rochester  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Elfar","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Center for Orthopaedics and Translational Science The Pennsylvania State University College of Medicine, Milton S. 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