{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T16:05:42Z","timestamp":1782403542474,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T00:00:00Z","timestamp":1563235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR 11BSV202552"],"award-info":[{"award-number":["ANR 11BSV202552"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003762","name":"Institut Pasteur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: No etiologic therapy is available for Duchenne muscular dystrophy (DMD), but mesenchymal stem cells were shown to be effective in preclinical models of DMD. The objective of this study is to investigate the effect of microfragmented fat extracted on a murine model of DMD. <jats:italic>Methods<\/jats:italic>: Fat tissue was extracted from healthy human participants and injected IM into DMD mice. Histological analysis, cytokines, and force measurement were performed up to 4 weeks after injection. <jats:italic>Results<\/jats:italic>: Duchenne muscular dystrophy mice injected with microfragmented fat exhibited an improved muscle phenotype (decreased necrosis and fibrosis), a decrease of inflammatory cytokines, and increased strength. <jats:italic>Discussion<\/jats:italic>: Administration of microfragmented fat in key muscles may improve muscular phenotype in patients with DMD. <jats:italic>Muscle Nerve<\/jats:italic>, 2019<\/jats:p>","DOI":"10.1002\/mus.26614","type":"journal-article","created":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T12:48:32Z","timestamp":1561207712000},"page":"328-335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Beneficial role of adipose\u2010derived mesenchymal stem cells from microfragmented fat in a murine model of duchenne muscular dystrophy"],"prefix":"10.1002","volume":"60","author":[{"given":"Adrien","family":"Bougl\u00e9","sequence":"first","affiliation":[{"name":"Infection and Epidemiology Department, Experimental Neuropathology Unit Institut Pasteur  Paris France"},{"name":"Sorbonne Universit\u00e9, Assistance Publique \u2010 H\u00f4pitaux de Paris, Department of Anesthesiology and Critical Care Medicine, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"},{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"},{"name":"Department of Anesthesiology and Critical Care Medicine Institute of Cardiology, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Rocheteau","sequence":"additional","affiliation":[{"name":"Infection and Epidemiology Department, Experimental Neuropathology Unit Institut Pasteur  Paris France"},{"name":"Service Hospitalo\u2010Universitaire, Centre Hospitalier Sainte Anne  Paris France"},{"name":"Laboratoire Universitaire de Neuropathologie Centre Hospitalier Sainte Anne  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Briand","sequence":"additional","affiliation":[{"name":"Infection and Epidemiology Department, Experimental Neuropathology Unit Institut Pasteur  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hardy","sequence":"additional","affiliation":[{"name":"Infection and Epidemiology Department, Experimental Neuropathology Unit Institut Pasteur  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Verdonk","sequence":"additional","affiliation":[{"name":"Infection and Epidemiology Department, Experimental Neuropathology Unit Institut Pasteur  Paris France"},{"name":"Sorbonne Universit\u00e9, Assistance Publique \u2010 H\u00f4pitaux de Paris, Department of Anesthesiology and Critical Care Medicine, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"},{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"},{"name":"Department of Anesthesiology and Critical Care Department Saint\u2010Antoine Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Tremolada","sequence":"additional","affiliation":[{"name":"Image Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Hivelin","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"},{"name":"Descartes University, Assistance Publique \u2010 H\u00f4pitaux de Paris, Department of Plastic Surgery, H\u00f4pital Europ\u00e9en Georges Pompidou  Paris France"},{"name":"Department of Plastic Surgery H\u00f4pital Europ\u00e9en Georges Pompidou  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Chr\u00e9tien","sequence":"additional","affiliation":[{"name":"Infection and Epidemiology Department, Experimental Neuropathology Unit Institut Pasteur  Paris France"},{"name":"Laboratoire Universitaire de Neuropathologie Centre Hospitalier Sainte Anne  Paris France"},{"name":"Descartes University, Assistance Publique \u2010 H\u00f4pitaux de Paris, Department of Plastic Surgery, H\u00f4pital Europ\u00e9en Georges Pompidou  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23528"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2012.301"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2006.09.016"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.05.025"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3990"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.4621"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.11.039"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2009.10.006"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05282"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042224"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2006.0118"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-016-9659-3"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368911X"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368914X681603"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X657855"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2009.05.008"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.05.009"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000412"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.03.032"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2016.00213"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.08.059"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21764"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00776.2015"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","unstructured":"VignaliDAA.Multiplexed particle\u2010based flow cytometric assays.2000;243(1\u20132):243\u2013255.","DOI":"10.1016\/S0022-1759(00)00238-6"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2011.181"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/14653240903131632"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.01.029"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240601114815"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi438"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000265074.83288.09"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2009.02.013"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.8.5.569"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2007.03.001"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.193244"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.26614","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.26614","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.26614","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.26614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T04:53:43Z","timestamp":1694321623000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.26614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,16]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1002\/mus.26614"],"URL":"https:\/\/doi.org\/10.1002\/mus.26614","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,16]]},"assertion":[{"value":"2018-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}