{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T10:31:55Z","timestamp":1752229915616,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T00:00:00Z","timestamp":1563408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>There are no validated, practical, and quantitative measures of disease severity in Lambert\u2010Eaton myasthenia (LEM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from the Effectiveness of 3,4\u2010Diaminopyridine in Lambert\u2010Eaton Myasthenic Syndrome (DAPPER) trial were analyzed to assess triple timed up\u2010and\u2010go (3TUG) reproducibility and relationships between 3TUG times and other measures of LEM severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The coverage probability technique showed \u22650.90 probability for an acceptable 3TUG difference of \u22640.2, indicating that it is reproducible in LEM patients. The correlation between 3TUG times and lower extremity function scores was significant in subjects who continued and in those who were withdrawn from 3,4\u2010diaminopyridine free base. Worsening patient\u2010reported Weakness Self\u2010Assessment Scale and Investigator Assessment of Treatment Effect scores corresponded with prolongation of 3TUG times.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The 3TUG is reproducible, demonstrates construct validity for assessment of lower extremity function in LEM patients, and correlates with changes in patient and physician assessments. These findings, along with prior reliability studies, indicate 3TUG is a valid measure of disease severity in LEM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26625","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T16:18:15Z","timestamp":1562170695000},"page":"292-298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Validation of the triple timed up\u2010and\u2010go test in Lambert\u2010Eaton myasthenia"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0216-1564","authenticated-orcid":false,"given":"Shruti M.","family":"Raja","sequence":"first","affiliation":[{"name":"Department of Neurology Duke University Medical Center  Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald B.","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Neurology Duke University Medical Center  Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vern C.","family":"Juel","sequence":"additional","affiliation":[{"name":"Department of Neurology Duke University Medical Center  Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yadollah","family":"Harati","sequence":"additional","affiliation":[{"name":"Department of Neurology Baylor College of Medicine  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Gordon","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Utah School of Medicine  Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Pascuzzi","sequence":"additional","affiliation":[{"name":"Department of Neurology Indiana University School of Medicine  Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David P.","family":"Richman","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California Davis Medical Center  Sacramento California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angie","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Predictive Modeling Duke Clinical Research Institute  Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy L.","family":"Ale\u0161","sequence":"additional","affiliation":[{"name":"Jacobus Pharmaceutical Company  Princeton New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura R.","family":"Jacobus","sequence":"additional","affiliation":[{"name":"Jacobus Pharmaceutical Company  Princeton New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David P.","family":"Jacobus","sequence":"additional","affiliation":[{"name":"Jacobus Pharmaceutical Company  Princeton New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey T.","family":"Guptill","sequence":"additional","affiliation":[{"name":"Department of Neurology Duke University Medical Center  Durham North Carolina"},{"name":"Neurosciences Medicine Duke Clinical Research Institute  Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the DAPPER Study Team","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(96)05303-8"},{"key":"e_1_2_10_3_1","first-page":"166","volume-title":"Neuromuscular Junction Disorders: Diagnosis and Treatment","author":"Meriggioli MN","year":"2004"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02329922"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.4.1143"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20332"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-015-0034-0"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.10.1324"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198912073212303"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb22949.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21422"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2009.35"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(78)85503-9"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(80)90378-7"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.3.603"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.60.2.127"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1991.tb01616.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/81.2.810"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20090126"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20080258"},{"key":"e_1_2_10_21_1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1093\/ptj\/86.5.646","article-title":"Timed \"Up & Go\" test: Reliability in older people dependent in activities of daily living\u2014focus on cognitive state","volume":"86","author":"Nordin E","year":"2006","journal-title":"Phys Ther."},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25700"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26052"},{"key":"e_1_2_10_24_1","first-page":"371","article-title":"The Lower Extremity Functional Scale (LEFS): Scale development, measurement properties, and clinical application. 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