{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T23:16:36Z","timestamp":1700608596602},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T00:00:00Z","timestamp":1564444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR052646"],"award-info":[{"award-number":["AR052646"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Dysferlin loss\u2010of\u2010function mutations cause muscular dystrophy, accompanied by impaired membrane repair and muscle weakness. Growth promoting strategies including insulin\u2010like growth factor 1 (IGF\u20101) could provide benefit but may cause strength loss or be ineffective. The objective of this study was to determine whether locally increased IGF\u20101 promotes functional muscle hypertrophy in dysferlin\u2010null (<jats:italic>Dysf<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup>) mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Muscle\u2010specific transgenic expression and postnatal viral delivery of <jats:italic>Igf1<\/jats:italic> were used in <jats:italic>Dysf<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> and control mice. Increased IGF\u20101 levels were confirmed by enzyme\u2010linked immunosorbent assay. Testing for skeletal muscle mass and function was performed in male and female mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Muscle hypertrophy occurred in response to increased IGF\u20101 in mice with and without dysferlin. Male mice showed a more robust response compared with females. Increased IGF\u20101 did not cause loss of force per cross\u2010sectional area in <jats:italic>Dysf<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> muscles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>We conclude that increased local IGF\u20101 promotes functional hypertrophy when dysferlin is absent and reestablishes IGF\u20101 as a potential therapeutic for dysferlinopathies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26641","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T16:44:34Z","timestamp":1563554674000},"page":"464-473","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Functional muscle hypertrophy by increased insulin\u2010like growth factor 1 does not require dysferlin"],"prefix":"10.1002","volume":"60","author":[{"given":"Elisabeth R.","family":"Barton","sequence":"first","affiliation":[{"name":"Anatomy and Cell Biology, School of Dental Medicine University of Pennsylvania  Philadelphia Pennsylvania"},{"name":"Applied Physiology and Kinesiology College of Health and Human Performance, University of Florida  Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Physiology, Perleman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Becky K.","family":"Brisson","sequence":"additional","affiliation":[{"name":"Anatomy and Cell Biology, School of Dental Medicine University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SooHyun","family":"Park","sequence":"additional","affiliation":[{"name":"Anatomy and Cell Biology, School of Dental Medicine University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Anatomy and Cell Biology, School of Dental Medicine University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physiology, Perleman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuozhen","family":"Tian","sequence":"additional","affiliation":[{"name":"Anatomy and Cell Biology, School of Dental Medicine University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W.","family":"Hammers","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, College of Medicine, University of Florida  Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Vassilakos","sequence":"additional","affiliation":[{"name":"Applied Physiology and Kinesiology College of Health and Human Performance, University of Florida  Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Lee","family":"Sweeney","sequence":"additional","affiliation":[{"name":"Department of Physiology, Perleman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania"},{"name":"Department of Pharmacology and Therapeutics, College of Medicine, University of Florida  Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2016.06.026"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200101)49:1<130::AID-ANA22>3.0.CO;2-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/1689"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/1682"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01573"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.41.532"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.5.871"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-7659com"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2006.07.004"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.5.855"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201858200"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2007.00573.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp121"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013854"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.066084"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq522"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401333"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1139\/h06-054"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00008.2014"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00955.2013"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01308.2009"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01405.2005"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00479.2003"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200108071"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/84839"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2014.06.003"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv288"},{"issue":"71","key":"e_1_2_8_29_1","first-page":"e50036","article-title":"Isometric and eccentric force generation assessment of skeletal muscles isolated from murine models of muscular dystrophies","author":"Moorwood C","year":"2013","journal-title":"J Vis Exp."},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21645"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-203026"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/2044-5040-4-21"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1992"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39845"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq065"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/134031"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200407021"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2005.11.003"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201800459R"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.20.12109"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0289fje"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21122-5"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.04.001"}],"container-title":["Muscle &amp; 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