{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T01:06:05Z","timestamp":1775091965872,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T00:00:00Z","timestamp":1565308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Therapeutic ultrasound has been suggested as a treatment for carpal tunnel syndrome (CTS), but existing trial evidence is of poor quality and inconclusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a randomized, controlled trial of therapeutic ultrasound in mild to moderate CTS. Forty patients were treated with wrist splints plus either real or sham therapeutic ultrasound and followed for 1\u2009year posttreatment. The primary outcome was change in symptom severity scale score. Secondary outcomes were functional status scale score, nerve conduction studies, and ultrasound imaging of the median nerve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both groups showed significant clinical and neurophysiological improvement at 6 and 12\u2009months compared with baseline. There were no significant differences between groups at any time. In a multivariate analysis, the only independently significant predictors of the primary outcome were pretreatment symptom severity and additional treatments during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>We found no clinically significant benefit from ultrasound treatment for CTS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26651","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T15:53:06Z","timestamp":1564501986000},"page":"538-543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ultrasound therapy adds no benefit to splinting in carpal tunnel syndrome"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1229-3843","authenticated-orcid":false,"given":"Kamalakannan P.","family":"Jothi","sequence":"first","affiliation":[{"name":"East Kent Hospitals University NHS Foundation Trust Kent and Canterbury Hospital  Canterbury Kent United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5591-6022","authenticated-orcid":false,"given":"Jeremy D. P.","family":"Bland","sequence":"additional","affiliation":[{"name":"East Kent Hospitals University NHS Foundation Trust Kent and Canterbury Hospital  Canterbury Kent United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhsu.2002.35074"},{"key":"e_1_2_9_3_1","first-page":"1","article-title":"Local corticosteroid injection for carpal tunnel syndrome (Review)","volume":"2","author":"Marshall SC","year":"2007","journal-title":"Cochrane Database Syst Rev."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753193417734426"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20802"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10209"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/81.7.1339"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/81.7.1351"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7133.731"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(98)90416-6"},{"issue":"12","key":"e_1_2_9_11_1","first-page":"659","article-title":"The comparison of ultrasound treatment and local steroid injection plus splinting in the carpal tunnel syndroe: a randomized controlled trial","volume":"111","author":"Bilgici A","year":"2010","journal-title":"Bratisl Lek Listy."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2014(08)04"},{"key":"e_1_2_9_13_1","first-page":"521","article-title":"Extracorporeal shock wave therapy and ultrasound therapy improve pain and function in patients with carpal tunnel syndrome. A randomized controlled trial","volume":"51","author":"Paoloni M","year":"2015","journal-title":"Eur J Phys Rehabil Med."},{"key":"e_1_2_9_14_1","first-page":"1","article-title":"Therapeutic ultrasound for carpal tunnel syndrome","author":"Page MJ","year":"2013","journal-title":"Cochrane Database Syst Rev."},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2017.08.482"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4598(200008)23:8<1280::AID-MUS20>3.0.CO;2-Y"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199311000-00002"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753193412442137"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-007-0471-1"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2006.01.012"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.26651","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.26651","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.26651","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.26651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T13:40:30Z","timestamp":1693748430000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.26651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,9]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1002\/mus.26651"],"URL":"https:\/\/doi.org\/10.1002\/mus.26651","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,9]]},"assertion":[{"value":"2019-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}