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FK506 rate of release testing and bioactivity assay was performed. Mouse sciatic nerve transection and direct repair model was used to evaluate the effect extended, local delivery of FK506 had on nerve regeneration outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Linear release of FK506 was observed for 30\u2009days and released FK506 matched control levels of neurite extension in the dorsal root ganglion assay. Groups treated with local FK506 had greater gastrocnemius muscle weight, foot electromyogram, and number of axons distal of the repair site than non\u2010FK506 groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Results of this study indicate that extended, localized delivery of FK506 to nerve injuries can improve nerve regeneration outcomes in a mouse sciatic nerve transection and repair.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26656","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T15:23:58Z","timestamp":1565364238000},"page":"613-620","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Local FK506 delivery at the direct nerve repair site improves nerve regeneration"],"prefix":"10.1002","volume":"60","author":[{"given":"Brett","family":"Davis","sequence":"first","affiliation":[{"name":"Department of Surgery University of Utah  Salt Lake City 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