{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T07:30:55Z","timestamp":1750404655130},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T00:00:00Z","timestamp":1567728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Although intravenous immune globulin (IVIg) is used to treat patients in the outpatient setting, there is limited documentation addressing the safety of this practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of 438 patients with neuromuscular diseases receiving IVIg in an outpatient setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adverse events (AE) overall occurred in 16.9% of patients. Headache was the most common AE, noted in 11.6% of patients. Serious AEs occurred in 0.91% of patients; aseptic meningitis was the only one noted. Multivariate analyses identified the following risk factors for AEs: first\u2010lifetime course of IVIg, higher dose per course of IVIg, diagnosis of myasthenia gravis, women, and younger age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Intravenous immune globulin is generally safe to administer in an outpatient setting. Women, myasthenia gravis patients, and those receiving their first course or a higher total dose of IVIg are at an increased risk of experiencing an AE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26678","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T21:44:54Z","timestamp":1566596694000},"page":"528-537","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Safety of intravenous immune globulin in an outpatient setting for patients with neuromuscular disease"],"prefix":"10.1002","volume":"60","author":[{"given":"Waqar","family":"Waheed","sequence":"first","affiliation":[{"name":"Department of Neurological Sciences University of Vermont, Robert Larner MD College of Medicine  Burlington Vermont"},{"name":"Department of Neurological Sciences University of Vermont Medical Center  Burlington Vermont"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gretchen A.","family":"Ayer","sequence":"additional","affiliation":[{"name":"Option Care Enterprises  Bannockburn Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy L.","family":"Jadoo","sequence":"additional","affiliation":[{"name":"South Shore Neurologic Associates  Islip New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary J.","family":"Badger","sequence":"additional","affiliation":[{"name":"Department of Medical Biostatistics University of Vermont  Burlington Vermont"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa","family":"Aboukhatwa","sequence":"additional","affiliation":[{"name":"Pharmacotherapy Service University of Vermont Medical Center  Burlington Vermont"},{"name":"Pharmacology Department, Medical Division National Research Center  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Thomas H.","family":"Brannagan","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rup","family":"Tandan","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences University of Vermont, Robert Larner MD College of Medicine  Burlington Vermont"},{"name":"Department of Neurological Sciences University of Vermont Medical Center  Burlington Vermont"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1088"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.223"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.4.1067"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.4.445"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360607"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns5.12046"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.59.3.248"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.5.766"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.60.6.699"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2014.971757"},{"issue":"8","key":"e_1_2_8_12_1","first-page":"CD003643","article-title":"Immunosuppressant and immunomodulatory treatment for dermatomyositis and polymyositis","author":"Gordon PA","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/CND.0b013e3182212589"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/CND.0b013e31818b2aef"},{"key":"e_1_2_8_15_1","first-page":"7","article-title":"IgIV at home: experience of a center\u2014economic aspects","volume":"28","author":"Hachulla E.","year":"2007","journal-title":"Rev Med Interne"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0094-3"},{"key":"e_1_2_8_17_1","unstructured":"EinodshoferMT. 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