{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T15:19:54Z","timestamp":1786375194138,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T00:00:00Z","timestamp":1568246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Large\u2010fiber neuropathy is rare in neurofibromatosis type 1, but small\u2010fiber neuropathy has not been studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with neurofibromatosis type 1 underwent nerve conduction studies for large\u2010fiber assessment. Small\u2010fiber tests included quantitative thermal thresholds, laser Doppler flare imaging, intraepidermal nerve fiber density, and corneal nerve fiber length.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 52 patients enrolled, 31 (60%) were female and the mean age was 33.0\u2009\u00b1\u200912.3\u2009years. Four (8%) patients had abnormal nerve conduction studies. Small\u2010fiber tests were frequently abnormal: thermal thresholds in 7 (13%); laser Doppler flare imaging in 10 (19%); intraepidermal nerve fiber density in 11 (22%); and corneal nerve fiber length in 27 (52%). The mean corneal nerve fiber length was below normative level (10.1\u2009\u00b1\u20092.7\u2009mm\/mm<jats:sup>3<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Small\u2010fiber neuropathy may be common in neurofibromatosis type 1, and should be investigated in symptomatic patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26687","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T15:48:20Z","timestamp":1567093700000},"page":"673-678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Evidence of small\u2010fiber neuropathy in neurofibromatosis type 1"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5546-0221","authenticated-orcid":false,"given":"Carolina","family":"Barnett","sequence":"first","affiliation":[{"name":"Elisabeth Raab Neurofibromatosis Clinic, Toronto General Hospital University Health 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H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Elisabeth Raab Neurofibromatosis Clinic, Toronto General Hospital University Health Network  Toronto Ontario Canada"},{"name":"Division of Medical Oncology and Hematology, Department of Medicine University of Toronto and University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanna M.","family":"McCuaig","sequence":"additional","affiliation":[{"name":"Elisabeth Raab Neurofibromatosis Clinic, Toronto General Hospital University Health Network  Toronto Ontario Canada"},{"name":"Division of Medical Oncology and Hematology, Department of Medicine University of Toronto and University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Kongkham","sequence":"additional","affiliation":[{"name":"Elisabeth Raab Neurofibromatosis Clinic, Toronto General Hospital University Health Network  Toronto Ontario 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