{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:47:54Z","timestamp":1773924474410,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:00:00Z","timestamp":1568073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Nerve cross\u2010sectional area (CSA) is larger than normal in Charcot\u2013Marie\u2013Tooth disease 1A (CMT1A), although to a variable extent. We explored whether CSA is correlated with CMT clinical severity measured with neuropathy score version 2 (CMTNS2) and its examination subscore (CMTES2) in CMT1A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed 56 patients with CMT1A (42 families). They underwent nerve conduction study (NCS) and nerve high\u2010resolution ultrasound (HRUS) of the left median, ulnar, and fibular nerves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Univariate analysis showed NCS and HRUS variables to be significantly correlated with CMTNS2 and CMTES2 and with each other. Multivariate analysis showed that ulnar motor nerve conduction velocity (\u03b2: \u22120.19) and fibular compound muscle action potential amplitude (\u22121.50) significantly influenced CMTNS2 and that median forearm CSA significantly influenced CMTNS2 (\u03b2: 5.29) and CMTES2 (4.28).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Nerve size is significantly associated with clinical scores in CMT1A, which suggests that it might represent a potential biomarker of CMT damage and progression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26688","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T15:50:05Z","timestamp":1567180205000},"page":"744-748","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Nerve size correlates with clinical severity in Charcot\u2013Marie\u2013Tooth disease 1A"],"prefix":"10.1002","volume":"60","author":[{"given":"Giampietro","family":"Zanette","sequence":"first","affiliation":[{"name":"Neurology Division Pederzoli Hospital  Peschiera del Garda, Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1561-2187","authenticated-orcid":false,"given":"Stefano","family":"Tamburin","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences University of Verona  Verona Italy"},{"name":"Neurology Division Department of Neuroscience AOUI Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Taioli","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences University of Verona  Verona Italy"},{"name":"Neurology Division Department of Neuroscience AOUI Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo Francesco","family":"Lauriola","sequence":"additional","affiliation":[{"name":"Neurology Division Pederzoli Hospital  Peschiera del Garda, Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Badari","sequence":"additional","affiliation":[{"name":"Neurology Division Pederzoli Hospital  Peschiera del Garda, Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moreno","family":"Ferrarini","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences University of Verona  Verona Italy"},{"name":"Neurology Division Department of Neuroscience AOUI Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Cavallaro","sequence":"additional","affiliation":[{"name":"Neurology Division Department of Neuroscience AOUI Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian 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