{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:42:24Z","timestamp":1790516544645,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In this study we investigate associations between genotypic and sociodemographic factors and the age of diagnosis of Duchenne muscular dystrophy (DMD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were collected from the Duchenne Registry from 2007 to 2019, and then used to assess the impact genotype, race\/ethnicity, neighborhood poverty levels, and other sociodemographics factors have on the age of diagnosis of DMD patients without a known family history, using univariate and multivariable linear regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of diagnosis was 4.43\u2009years. Non\u2010Caucasian patients and patients from high\u2010poverty neighborhoods were older at diagnosis (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). Increased year of birth was associated with decreasing age of diagnosis (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Specific genetic mutation subtypes were associated with later ages of symptom onset and diagnosis (<jats:italic>P<\/jats:italic> = .005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>After adjusting for genotype and year of birth, the average age of diagnosis was significantly later for traditionally at\u2010risk patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26720","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T12:30:00Z","timestamp":1569933000000},"page":"36-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Delays in diagnosis of Duchenne muscular dystrophy: An evaluation of genotypic and sociodemographic factors"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9921-9640","authenticated-orcid":false,"given":"Kevin J.","family":"Counterman","sequence":"first","affiliation":[{"name":"Department of Research Parent Project Muscular Dystrophy  Hackensack New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pat","family":"Furlong","sequence":"additional","affiliation":[{"name":"Department of Research Parent Project Muscular Dystrophy  Hackensack New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2483-3205","authenticated-orcid":false,"given":"Richard T.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Human Genetics David Geffen School of Medicine, University of California Los Angeles  California"},{"name":"Center for Duchenne Muscular Dystrophy University of California Los Angeles, Los Angeles  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann S.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Research Parent Project Muscular Dystrophy  Hackensack New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/323646a0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.02.007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2017.02.006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/ejpn.2000.0309"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)05279-9"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.10.043"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.301"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e31822623f1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-306366"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3233\/JND-160185"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23561"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002891"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/currents.RRN1309"},{"key":"e_1_2_8_15_1","article-title":"Online self\u2010reported data for Duchenne muscular dystrophy confirms natural history and can be used to assess therapeutic benefits","volume":"6","author":"Wang RT","year":"2014","journal-title":"PLoS Curr."},{"key":"e_1_2_8_16_1","unstructured":"Parent Project Muscular Dystrophy. 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