{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T16:53:38Z","timestamp":1778086418000,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:00:00Z","timestamp":1571270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Disuse atrophy from immobilization is the result of decreased neural activity and muscle unloading.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied the impact of disuse on hand intrinsic compound muscle action potentials (CMAPs) in a cohort of 39 patients with unilateral 6\u2010week immobilization of the hand in a cast, after distal radius fracture. We excluded patients with nerve injury. We compared side\u2010to\u2010side CMAP characteristics at the time of cast removal and at a subsequent follow\u2010up visit, after a mean interval of 7.8\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Statistically significant reductions in CMAP amplitude were noted for the abductor pollicis brevis (29.2%), abductor digiti minimi (19.0%), and first dorsal interosseus (24.9%). There was partial repair of the relative CMAP reduction at the follow\u2010up visit (20.1%, 10.7%, and 8.7%, respectively). There was no significant change in CMAP duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results provide a framework for quantifying the degree of hand intrinsic CMAP amplitude reduction attributed to disuse.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26730","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T06:34:45Z","timestamp":1570430085000},"page":"58-62","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Impact of disuse muscular atrophy on the compound muscle action potential"],"prefix":"10.1002","volume":"61","author":[{"given":"Theo","family":"Mobach","sequence":"first","affiliation":[{"name":"Division of Neurology (Medicine) University of Ottawa, The Ottawa Hospital  Ottawa Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Brooks","sequence":"additional","affiliation":[{"name":"Division of Neurology (Medicine) University of Ottawa, The Ottawa Hospital  Ottawa Canada"},{"name":"The Ottawa Hospital Research Institute  Ottawa Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ari","family":"Breiner","sequence":"additional","affiliation":[{"name":"Division of Neurology (Medicine) University of Ottawa, The Ottawa Hospital  Ottawa Canada"},{"name":"The Ottawa Hospital Research Institute  Ottawa Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jodi","family":"Warman\u2010Chardon","sequence":"additional","affiliation":[{"name":"Division of Neurology (Medicine) University of Ottawa, The Ottawa Hospital  Ottawa Canada"},{"name":"The Ottawa Hospital Research Institute  Ottawa Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Papp","sequence":"additional","affiliation":[{"name":"Division of Orthopedic Surgery University of Ottawa, The Ottawa Hospital  Ottawa Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Braden","family":"Gammon","sequence":"additional","affiliation":[{"name":"Division of Orthopedic Surgery University of Ottawa, The Ottawa Hospital  Ottawa Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeev D.","family":"Nandedkar","sequence":"additional","affiliation":[{"name":"Natus Medical Inc, Hopewell Junction  New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7455-0254","authenticated-orcid":false,"given":"Pierre R.","family":"Bourque","sequence":"additional","affiliation":[{"name":"Division of Neurology (Medicine) University of Ottawa, The Ottawa Hospital  Ottawa Canada"},{"name":"The Ottawa Hospital Research Institute  Ottawa Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2008.08.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.06.011"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2010.06.025"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25204"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199804)21:4<498::AID-MUS8>3.0.CO;2-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067113"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2018.09.025"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21838"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.6.799"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21733"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00611.2012"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0273-1177(02)00395-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1249\/00003677-199101000-00008"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00257.2016"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22864"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjsem-2016-000196"},{"issue":"5","key":"e_1_2_7_18_1","first-page":"305","article-title":"Conduction block and abnormal temporal dispersion\u2013diagnostic criteria","volume":"37","author":"Weber F","year":"1997","journal-title":"Electromyogr Clin Neurophysiol."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880170504"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.035188"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-0272-z"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25732"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20304"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.26730","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.26730","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.26730","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.26730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T23:39:38Z","timestamp":1693870778000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.26730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,17]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1002\/mus.26730"],"URL":"https:\/\/doi.org\/10.1002\/mus.26730","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,17]]},"assertion":[{"value":"2019-06-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}