{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T14:20:39Z","timestamp":1761402039092,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We assess whether improvement in control of type 1 diabetes mellitus (T1DM) with continuous subcutaneous insulin infusion (CSII) can protect peripheral nerve function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twelve patients with T1DM treated with multiple daily insulin injections were assessed with nerve excitability testing prior to and 3\u2009months after initiation of CSII.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although commencing treatment with CSII for 3\u2009months improved mean glycosylated hemoglobin, it did not significantly alter nerve excitability or glycemic variability (GV). In four patients, some deterioration in GV was observed, while eight patients had improvement in SD and mean amplitude of glycemic excursions. For these eight patients, there was normalization of depolarizing and hyperpolarizing threshold electrotonus and recovery cycle superexcitablity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>When CSII initiation is able to reduce glycemic variability in T1DM, reversal of axonal dysfunction is seen, likely due to normalization of sodium\u2010potassium pump function and restoration of transaxonal membrane potential.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26738","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T22:50:41Z","timestamp":1571179841000},"page":"44-51","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Reducing glucose variability with continuous subcutaneous insulin infusion is associated with reversal of axonal dysfunction in type 1 diabetes mellitus"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3650-2622","authenticated-orcid":false,"given":"Jordan","family":"Kamel","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurological Research St Vincent's Hospital Melbourne  Melbourne Victoria Australia"},{"name":"Department of Medicine The University of Melbourne  Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Loh","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes St Vincent's Hospital Melbourne  Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological Research St Vincent's Hospital Melbourne  Melbourne Victoria Australia"},{"name":"Department of Medicine The University of Melbourne  Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"MacIsaac","sequence":"additional","affiliation":[{"name":"Department of Medicine The University of Melbourne  Victoria Australia"},{"name":"Department of Endocrinology and Diabetes St Vincent's Hospital Melbourne  Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie J.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological Research St Vincent's Hospital Melbourne  Melbourne Victoria Australia"},{"name":"Department of Medicine The University of Melbourne  Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,6]]},"reference":[{"issue":"4","key":"e_1_2_9_2_1","first-page":"E311","article-title":"Impaired energy utilization and Na\u2010K\u2010ATPase in diabetic peripheral nerve","volume":"246","author":"Greene 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