{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:25Z","timestamp":1786978225612,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>With improved treatments, patients with Duchenne muscular dystrophy (DMD) can survive far beyond adolescence. However, advanced\u2010stage DMD patients are at risk of developing renal dysfunction. In this study, long\u2010term renal function outcomes and associated risk factors in advanced stage DMD were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty\u2010one patients were classified into three different age groups (&lt;20, 20\u201329, and\u2009\u226530\u2009years of age), and cystatin C (CysC) levels were compared among groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median serum CysC levels were 0.74\u2009mg\/L, 0.63\u2009mg\/L, and 0.76\u2009mg\/L in the age groups of &lt;20, 20\u201329, and\u2009\u226530\u2009years, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      = .003). Five of the nine patients in the \u226530\u2009years age group showed elevated serum CysC and decreased cardiac function compared with the other four in the group (\n                      <jats:italic>P<\/jats:italic>\n                      = .014).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our results indicate an association between cardiac and renal dysfunction in patients with advanced\u2010stage DMD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.26757","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T12:26:21Z","timestamp":1573734381000},"page":"192-197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Renal dysfunction can occur in advanced\u2010stage Duchenne muscular dystrophy"],"prefix":"10.1002","volume":"61","author":[{"given":"Takahiro","family":"Motoki","sequence":"first","affiliation":[{"name":"Department of Pediatrics Ehime University Graduate School of Medicine  Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Shimizu\u2010Motohashi","sequence":"additional","affiliation":[{"name":"Department of Child Neurology, National Center Hospital National Center of Neurology and Psychiatry  Kodaira Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Public Health and Epidemiology, Faculty of Medicine Oita University  Yufu Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Komaki","sequence":"additional","affiliation":[{"name":"Translational Medical Center National Center Hospital, National Center of Neurology and Psychiatry  Kodaira Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Ishiyama","sequence":"additional","affiliation":[{"name":"Department of Child Neurology, National Center Hospital National Center of Neurology and Psychiatry  Kodaira Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Aibara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ehime University Graduate School of Medicine  Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Jogamoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ehime University Graduate School of Medicine  Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Tezuka","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Ehime Prefectural Niihama Hospital  Niihama Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Kawabe","sequence":"additional","affiliation":[{"name":"Ehime Rehabilitation Center for Children  Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Makino","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Ehime Prefectural Niihama Hospital  Niihama Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Nagatani","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Uwajima City Hospital  Uwajima Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Tatara","sequence":"additional","affiliation":[{"name":"Division of Child Neurology Shikoku Medical Center for Children and Adults  Zentsuji Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozue","family":"Kuwabara","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Ehime Prefectural Central Hospital  Matsuyama Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiya","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Division of Pediatrics National Hospital Organization Ehime Medical Center  Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsumasa","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology Tokyo Metropolitan Neurological Hospital  Fuchu Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichi","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ehime University Graduate School of Medicine  Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ehime University Graduate School of Medicine  Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23528"},{"key":"e_1_2_9_3_1","first-page":"470","article-title":"Managing Duchenne muscular dystrophy: the additive effect of spinal surgery and home nocturnal ventilation in improving survival","volume":"27","author":"Engle M","year":"2007","journal-title":"Neuromuscul Disord."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2016.09.019"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(02)00140-2"},{"key":"e_1_2_9_6_1","first-page":"CD003725","article-title":"Glucocorticoid corticosteroids for 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