{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:23:31Z","timestamp":1790731411185,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T00:00:00Z","timestamp":1575936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Rest\u2010activity disruption is an important feature of Duchenne muscular dystrophy (DMD). We sought to describe sleep impairment and its relationship to quality of life (QOL) and to evaluate associations between rest\u2010activity, sleep quality, and 6\u2010minute walk test (6MWT) in DMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sleep impairment and its relationship to QOL was assessed by questionnaire in 54 children (33 ambulatory, 21 nonambulatory) with DMD. Rest\u2010activity characteristics were calculated for 23 of these children (14 ambulatory, nine nonambulatory) by actigraphy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pathologic sleep was reported in 11 (20%) participants and correlated with lower QOL but not with ambulatory status. In ambulatory participants who completed actigraphy, rest\u2010activity rhythm fragmentation was associated with subjective sleep impairment. Habitual daytime activity level was associated with 6MWT performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Children with DMD experience substantial sleep impairment that is related to QOL. Wrist actigraphy may be a parsimonious tool for monitoring both sleep and motor impairment in ambulatory children with DMD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.26759","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T12:24:56Z","timestamp":1573734296000},"page":"198-204","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Use of a wearable device to assess sleep and motor function in Duchenne muscular dystrophy"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3022-6719","authenticated-orcid":false,"given":"Benjamin I.","family":"Siegel","sequence":"first","affiliation":[{"name":"Department of Pediatrics Emory University School of Medicine  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse","family":"Cakmak","sequence":"additional","affiliation":[{"name":"School of Electrical and Computer Engineering Georgia Institute of Technology  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Reinertsen","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology &amp; Emory University School of Medicine  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macarthur","family":"Benoit","sequence":"additional","affiliation":[{"name":"Children's Healthcare of Atlanta  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Figueroa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Emory University School of Medicine  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gari D.","family":"Clifford","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology &amp; Emory University School of Medicine  Atlanta Georgia"},{"name":"Department of Biomedical Informatics Emory University School of Medicine  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han C.","family":"Phan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Emory University School of Medicine  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rehab.2013.06.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(02)00140-2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2005.00691.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.12.006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12025"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1550232"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073815627879"},{"key":"e_1_2_8_9_1","article-title":"The 6\u2010minute walk test and person\u2010reported outcomes in boys with duchenne muscular dystrophy and typically developing controls: longitudinal comparisons and clinically\u2010meaningful changes over one year","volume":"5","author":"Henricson E","year":"2013","journal-title":"PLoS Curr."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23905"},{"issue":"89","key":"e_1_2_8_11_1","first-page":"233","article-title":"Orphan drug development in muscular dystrophy: update on two large clinical trials of dystrophin rescue therapies","volume":"16","author":"Hoffman EP","year":"2013","journal-title":"Discov Med."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.5836"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2010.10.001"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420529908998724"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2014.06.002"},{"key":"e_1_2_8_16_1","first-page":"1","article-title":"Fragmentation of daily rhythms associates with obesity and cardiorespiratory fitness in adolescents: the HELENA study","author":"Garaulet M","year":"2016","journal-title":"Clin Nutr."},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073814530502"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2004.10.012"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3233\/JND-160195"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12348"},{"key":"e_1_2_8_21_1","unstructured":"ActiGraph. Catabasis and ActiGraph collaborate on an observational trial to explore the benefits of daily physiological activity monitoring in patients with Duchenne muscular dystrophy.http:\/\/actigraphcorp.com\/news-article\/catabasis-and-actigraph-collaborate-on-an-observational-trial-to-explore-the-benefits-of-daily-physiological-activity-monitoring-in-patients-with-duchenne-muscular-dystrophy\/. Published2015. Accessed November 20 2019."},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2009.06.185"},{"key":"e_1_2_8_23_1","unstructured":"US National Library of Medicine. Natural history of Duchenne muscular dystrophy.ClinicalTrials.govidentifier: NCT03882827.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03882827. Published2019. Accessed November 20 2019."},{"key":"e_1_2_8_24_1","unstructured":"US National Library of Medicine. 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In: Proceedings of the SAS Global Forum2012; April 22\u201325 2012; Cary North Carolina.https:\/\/www.semanticscholar.org\/paper\/A-unified-approach-to-measuring-the-effect-size-two-Yang-Dalton\/6cf4bd36ca4c90006a5d6563f646a391c255581b. 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