{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:12:45Z","timestamp":1790291565939,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Our research aim was to develop a novel clinimetric scale sensitive enough to detect disease progression in primary lateral sclerosis (PLS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prototype of the PLS Functional Rating Scale (PLSFRS) was generated. Seventy\u2010seven participants with PLS were enrolled and evaluated at 21 sites that comprised the PLSFRS study group. Participants were assessed using the PLSFRS, Neuro\u2010Quality of Life (QoL), Schwab\u2010England Activities of Daily Living (ADL), and the Clinical Global Impression of Change scales. Participants completed telephone assessments at 12, 24, and 48\u2009weeks after enrollment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PLSFRS demonstrated internal consistency as well as intrarater, interrater, telephone test\u2010retest reliability, and construct validity. Significant changes in disease progression were detected at 6 and 12\u2009months; changes measured by the PLSFRS vs the ALSFRS\u2010R were significantly higher.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The PLSFRS is a valid tool to assess the natural history of PLS in a shorter study period.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26765","type":"journal-article","created":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T06:29:25Z","timestamp":1574490565000},"page":"163-172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Primary lateral sclerosis (PLS) functional rating scale: PLS\u2010specific clinimetric scale"],"prefix":"10.1002","volume":"61","author":[{"given":"Hiroshi","family":"Mitsumoto","sequence":"first","affiliation":[{"name":"Department of Neurology, Eleanor and Lou Gehrig ALS Center Columbia University Irvine Medical Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Codruta","family":"Chiuzan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Mailman School of Medicine, Columbia University  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison","family":"Gilmore","sequence":"additional","affiliation":[{"name":"Department of Neurology, Eleanor and Lou Gehrig ALS Center Columbia University Irvine Medical Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Mailman School of Medicine, Columbia University  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8574-5332","authenticated-orcid":false,"given":"Zachary","family":"Simmons","sequence":"additional","affiliation":[{"name":"Department of Neurology Pennsylvania State University  Hershey Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Paganoni","sequence":"additional","affiliation":[{"name":"Sean M. Healey &amp; AMG Center for ALS, Department of Neurology Massachusetts General Hospital  Boston Massachusetts"},{"name":"Department of Physical Medicine and Rehabilitation Spaulding Rehabilitation Hospital, Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi Y.","family":"Kisanuki","sequence":"additional","affiliation":[{"name":"Department of Neurology The Ohio State University  Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorne","family":"Zinman","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Toronto, Sunnybrook Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Jawdat","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Kansas  Kansas City Kansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Sorenson","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic, Minnesota  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Kay","family":"Floeter","sequence":"additional","affiliation":[{"name":"Clinical Unit, National Institute of Neurological Diseases and Stroke  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik P.","family":"Pioro","sequence":"additional","affiliation":[{"name":"Department of Neurology Cleveland Clinic  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Americo M.","family":"Fernandes Filho","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Nebraska  Omaha Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daragh","family":"Heitzman","sequence":"additional","affiliation":[{"name":"Texas Neurology  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina Nicole","family":"Fournier","sequence":"additional","affiliation":[{"name":"Department of Neurology Emory University and Atlanta VA Medical Center  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjorn","family":"Oskarsson","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Jacksonville  Jacksonville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Heiman\u2010Patterson","sequence":"additional","affiliation":[{"name":"Department of Neurology Temple University  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Maragakis","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanette","family":"Joyce","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California Davis  Davis California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazala","family":"Hayat","sequence":"additional","affiliation":[{"name":"Department of Neurology St Louis University  St Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Nations","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Texas Southwestern  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Scelsa","sequence":"additional","affiliation":[{"name":"Department of Neurology Mount Sinai\/Beth Israel Hospital  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Walk","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Minnesota  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Elman","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Hupf","sequence":"additional","affiliation":[{"name":"Department of Neurology, Eleanor and Lou Gehrig ALS Center Columbia University Irvine Medical Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"McHale","sequence":"additional","affiliation":[{"name":"Department of Neurology, Eleanor and Lou Gehrig ALS Center Columbia University Irvine Medical Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the PLSFRS study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23496"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181a8269b"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.NXG.0000464294.88607.dd"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/17482960802411740"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2013.794843"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.10.024"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.03.018"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2018.1517180"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2018.1550518"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1996.00550020045014"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00210-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434470410019906"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70129-2"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30115-1"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2013.864312"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434470410019753"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-011-9958-8"},{"key":"e_1_2_9_19_1","unstructured":"SchwabRS EnglandAC.Projection techniques for evaluating surgery in Parkinson's Disease.Third Symposium on Parkinson's Disease Royal College of Surgeons. Edinburgh: Churchill Livingstone;1969:152\u2013159."},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.7.937"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/14660820510027107"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/17482960600888156"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000200962.94777.71"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2014.942668"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6251-2"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.2196\/resprot.8655"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.26765","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.26765","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.26765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T06:48:23Z","timestamp":1694155703000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.26765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,13]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1002\/mus.26765"],"URL":"https:\/\/doi.org\/10.1002\/mus.26765","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,13]]},"assertion":[{"value":"2019-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}