{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T03:38:18Z","timestamp":1775705898304,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T00:00:00Z","timestamp":1575590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HD082109"],"award-info":[{"award-number":["R01 HD082109"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HD084645"],"award-info":[{"award-number":["R01 HD084645"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS094387"],"award-info":[{"award-number":["R01 NS094387"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neurophysiologic biomarkers are needed for clinical trials of therapies for myotonic dystrophy (DM1). We characterized muscle properties, spinal reflexes (H\u2010reflexes), and trans\u2010cortical long\u2010latency reflexes (LLRs) in a cohort with mild\/moderate DM1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010four people with DM1 and 25 matched controls underwent assessment of tibial nerve H\u2010reflexes and soleus muscle twitch properties. Quadriceps LLRs were elicited by delivering an unexpected perturbation during a single\u2010limb squat (SLS) visuomotor tracking task.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DM1 was associated with decreased H\u2010reflex depression. The efficacy of doublet stimulation was enhanced, yielding an elevated double\u2010single twitch ratio. DM1 participants demonstrated greater error during the SLS task. DM1 individuals with the least\u2010robust LLR responses showed the greatest loss of spinal H\u2010reflex depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DM1 is associated with abnormalities of muscle twitch properties. Co\u2010occurring alterations of spinal and trans\u2010cortical reflex properties underscore the central nervous system manifestations of this disorder and may assist in gauging efficacy during clinical trials.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26767","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T01:43:18Z","timestamp":1574818998000},"page":"205-212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Myotonic dystrophy type 1 alters muscle twitch properties, spinal reflexes, and perturbation\u2010induced trans\u2010cortical reflexes"],"prefix":"10.1002","volume":"61","author":[{"given":"Richard K.","family":"Shields","sequence":"first","affiliation":[{"name":"Department of Physical Therapy and Rehabilitation Science, Roy J. and Lucille A. Carver College of Medicine University of Iowa  Iowa City Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Rehabilitation Science, Roy J. and Lucille A. Carver College of Medicine University of Iowa  Iowa City Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Buelow","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Rehabilitation Science, Roy J. and Lucille A. Carver College of Medicine University of Iowa  Iowa City Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Petrie","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Rehabilitation Science, Roy J. and Lucille A. Carver College of Medicine University of Iowa  Iowa City Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shauna","family":"Dudley\u2010Javoroski","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Rehabilitation Science, Roy J. and Lucille A. Carver College of Medicine University of Iowa  Iowa City Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Cross","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine University of Iowa  Iowa City Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie","family":"Gutmann","sequence":"additional","affiliation":[{"name":"Department of Neurology, Roy J. and Lucille A. 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