{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:15:49Z","timestamp":1787242549934,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,11]],"date-time":"2020-01-11T00:00:00Z","timestamp":1578700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>In this study we aimed to clarify the association between interleukin\u20106 (IL\u20106) secretion in fibroblasts in carpal tunnel syndrome (CTS) patients and their biophysical parameters, including association with trigger finger and whether tranilast inhibits IL\u20106 secretion in fibroblasts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fibroblasts were obtained from tenosynovial tissue harvested from idiopathic CTS patients undergoing carpal tunnel release and tenosynovectomy and cultured in media containing tranilast with or without tumor necrosis\u2010\u03b1 (TNF\u2010\u03b1) or interleukin\u20101\u03b2 (IL\u20101\u03b2). Their proliferation was evaluated and secreted IL\u20106 levels and IL\u20106 mRNA expression were quantified. Correlations between IL\u20106 concentration and patient characteristics were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      IL\u20106 secretion was significantly associated with trigger finger (\n                      <jats:italic>P<\/jats:italic>\n                      = .001). Tranilast inhibited fibroblast proliferation in a dose\u2010dependent manner and suppressed IL\u20106 secretion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>IL\u20106 overproduction in tenosynovial tissue may account for the association between CTS and trigger finger. Future studies should investigate whether tranilast can be used to treat patients with CTS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.26793","type":"journal-article","created":{"date-parts":[[2019,12,28]],"date-time":"2019-12-28T02:15:06Z","timestamp":1577499306000},"page":"408-415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Interleukin\u20106 secretion by fibroblasts in carpal tunnel syndrome patients is associated with trigger finger and inhibited by tranilast"],"prefix":"10.1002","volume":"61","author":[{"given":"Hiroya","family":"Kawamoto","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Yokkaichi Municipal Hospital  Mie Japan"},{"name":"Department of Hand Surgery Nagoya University Graduate School of Medicine  Nagoya 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