{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:01:42Z","timestamp":1767852102668,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The 6\u2010minute walk test (6MWT) is a well\u2010established clinical assessment of functional endurance, validated as a measure of walking ability in spinal muscular atrophy (SMA). The current availability of disease\u2010modifying therapies for SMA indicates a growing need for normative reference data to compare SMA patients with healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The literature was searched in two scientific databases. Studies were evaluated and selected based on adherence to American Thoracic Society guidelines for administering the 6MWT. Reference equations from the selected studies were applied to 6MWT data collected from SMA patients to calculate and compare % predicted values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three pediatric and six adult studies were selected for comparison. The % predicted values using the pediatric and adult equations ranged from 47.7\u2009\u00b1\u200918.2% to 67.6\u2009\u00b1\u200926.2% and 43.0\u2009\u00b1\u200917.9% to 59.5\u2009\u00b1\u200926.2%, respectively, and were significantly different (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Results suggest significant variability between % predicted values derived from published reference equations in children and adults, despite adherence to 6MWT standardization.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26794","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T02:32:30Z","timestamp":1577673150000},"page":"375-382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Limitations of 6\u2010minute walk test reference values for spinal muscular atrophy"],"prefix":"10.1002","volume":"61","author":[{"given":"Ashley M.","family":"Goodwin","sequence":"first","affiliation":[{"name":"Department of Rehabilitation and Regenerative Medicine Program in Physical Therapy, Columbia University Irving Medical Center New York New York"},{"name":"Teachers College Columbia University New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayla M.D.","family":"Cornett","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Irving Medical Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marnee J.","family":"McKay","sequence":"additional","affiliation":[{"name":"The University of Sydney &amp; The Children's Hospital at Westmead Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Burns","sequence":"additional","affiliation":[{"name":"The University of Sydney &amp; The Children's Hospital at Westmead Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol Ewing","family":"Garber","sequence":"additional","affiliation":[{"name":"Teachers College Columbia University New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darryl C.","family":"De Vivo","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Irving Medical Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Montes","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Regenerative Medicine Program in Physical Therapy, Columbia University Irving Medical Center New York New York"},{"name":"Department of Neurology Columbia University Irving Medical Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25120"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4508"},{"issue":"15","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"P2.322","DOI":"10.1212\/WNL.90.15_supplement.P2.322","article-title":"Ambulatory function and fatigue in nusinersen\u2010treated children with spinal muscular atrophy. (P2.322)","volume":"90","author":"Montes J","year":"2018","journal-title":"Neurology"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2019.09.007"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.152"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3233\/JND-199001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26633"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007527"},{"issue":"5","key":"e_1_2_9_10_1","first-page":"381","article-title":"Reference values for the 6\u2010minute walk test in healthy children and adolescents: a systematic review","volume":"31","author":"Cacau LA","year":"2016","journal-title":"Braz J Cardiovasc Surg."},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0066-782X2011005000024"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2016.1258305"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2014.10.002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.12.052"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.5.9710086"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008483-200103000-00005"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073813493663"},{"issue":"3","key":"e_1_2_9_19_1","first-page":"193","article-title":"Six\u2010minute walking test: normal reference values for Taiwanese children and adolescents","volume":"31","author":"Chen CA","year":"2015","journal-title":"Acta Cardiol Sin."},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003847"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22696"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hkpj.2014.04.003"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.01.001"},{"issue":"5","key":"e_1_2_9_24_1","first-page":"CC01","article-title":"Reference equation for 6 minute walk test in healthy western India population","volume":"10","author":"Fernandes L","year":"2016","journal-title":"J Clin Diagn Res."},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-2113.125892"},{"issue":"50","key":"e_1_2_9_26_1","first-page":"97","article-title":"Six minute walk distance and reference equations in normal healthy subjects of Nepal","volume":"13","author":"Shrestha SK","year":"2015","journal-title":"Kathmandu Univ Med j (KUMJ)."},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00150314"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/CND.0000000000000181"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24332"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/currents.RRN1297"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEP.0b013e3182a635f0"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24670"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26345"},{"issue":"4","key":"e_1_2_9_34_1","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1002\/mus.21025","article-title":"Clinical features of late\u2010onset Pompe disease: a prospective cohort study","volume":"38","author":"Wokke JHJ","journal-title":"Muscle Nerve"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31408-8"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2017.45"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d3e308"}],"container-title":["Muscle &amp; 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